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The use of polymeric clips in securing the appendiceal stump during laparoscopic appendicectomy: a systematic review

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Abstract

Purpose

A key step during laparoscopic appendicectomy is securing the appendiceal stump. This has traditionally been achieved using vicryl endoloops, but increasing evidence suggests that the use of polymeric clips (Hem-o-lok) may be a safe and viable method. Current evidence for its clinical use in laparoscopic appendicectomy is unknown. We performed a systematic review of the literature examining the clinical outcomes of laparoscopic appendicectomy using polymeric clips compared to other methods of stump closure.

Methods

A systematic literature review based on PRISMA guidelines was performed using MEDLINE, PubMed, EMBASE and Cochrane library databases between 2000 and 2017. All studies analysing appendiceal stump closure during laparoscopic appendicectomy using polymeric clips compared to other methods of stump closure were included. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Reviews. The review was registered with the PROSPERO register of systematic reviews.

Results

Ten studies were included, involving 702 patients, 7 of which were prospective studies and 1 a randomised control trial. Polymeric clips were found to be the cheapest method (€20.47 average per patient) and also had the lowest rate of complications (2.7%) compared to other commonly used closure methods. Meanwhile, operative time and duration of in-patient stay were similar between groups.

Conclusions

Current evidence suggests that polymeric clips are an effective and cost-efficient method for stump closure in laparoscopic appendicectomy for acute appendicitis. Further high-quality evidence is required before polymeric clips can be recommended as the gold standard for appendiceal stump closure.

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References

  1. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132(5):910–25.

    Article  CAS  PubMed  Google Scholar 

  2. Lee JH, Park YS, Choi JS. The epidemiology of appendicitis and appendectomy in South Korea: national registry data. J Epidemiol. 2010;20(2):97–105.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Semm K. Endoscopic appendectomy. Endoscopy. 1983;15(2):59–64. https://doi.org/10.1055/s-2007-1021466.

    Article  CAS  PubMed  Google Scholar 

  4. Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, et al. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11:34. https://doi.org/10.1186/s13017-016-0090-5.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Beldi G, Muggli K, Helbling C, Schlumpf R. Laparoscopic appendectomy using endoloops: a prospective, randomized clinical trial. Surg Endosc. 2004;18(5):749–50. https://doi.org/10.1007/s00464-003-9156-z.

    Article  CAS  PubMed  Google Scholar 

  6. Beldi G, Vorburger SA, Bruegger LE, Kocher T, Inderbitzin D, Candinas D. Analysis of stapling versus endoloops in appendiceal stump closure. Br J Surg. 2006;93(11):1390–3. https://doi.org/10.1002/bjs.5474.

    Article  CAS  PubMed  Google Scholar 

  7. Yang HR, Wang YC, Chung PK, Jeng LB, Chen RJ. Laparoscopic appendectomy using the LigaSure vessel sealing system. J Laparoendosc Adv Surg Tech. 2005;15(4):353–6. https://doi.org/10.1089/lap.2005.15.353.

    Article  CAS  Google Scholar 

  8. Delibegovic S, Matovic E. Hem-o-lok plastic clips in securing of the base of the appendix during laparoscopic appendectomy. Surg Endosc. 2009;23(12):2851–4. https://doi.org/10.1007/s00464-009-0493-4.

    Article  PubMed  Google Scholar 

  9. Hanssen A, Plotnikov S, Dubois R. Laparoscopic appendectomy using a polymeric clip to close the appendicular stump. JSLS. 2007;11(1):59–62.

    PubMed  PubMed Central  Google Scholar 

  10. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Oanda Average Exchange Rates. https://www.oanda.com/currency/average. Accessed 16 Aug 2016.

  12. Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions, version 5.1.0. London: The Cochrane Collaboration; 2011.

    Google Scholar 

  13. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13. https://doi.org/10.1186/1471-2288-5-13.

    Article  PubMed  PubMed Central  Google Scholar 

  14. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2013. http://www.r-project.org/. Accessed 14 Jan 2018.

  15. Partecke LI, Kessler W, von Bernstorff W, Diedrich S, Heidecke CD, Patrzyk M. Laparoscopic appendectomy using a single polymeric clip to close the appendicular stump. Langenbecks Arch Surg. 2010;395(8):1077–82. https://doi.org/10.1007/s00423-010-0671-9.

    Article  PubMed  Google Scholar 

  16. Hue CS, Kim JS, Kim KH, Nam SH, Kim KW. The usefulness and safety of Hem-o-lok clips for the closure of appendicular stump during laparoscopic appendectomy. J Korean Surg Soc. 2013;84(1):27–32. https://doi.org/10.4174/jkss.2013.84.1.27.

    Article  PubMed  Google Scholar 

  17. Colak E, Kement M, Ozlem N, Mutlu T, Yildirim K, Gurer A, et al. A comparison of nonabsorbable polymeric clips and endoloop ligatures for the closure of the appendicular stump in laparoscopic appendectomy: a prospective, randomized study. Surg Laparosc Endosc Percutaneous Tech. 2013;23(3):255–8. https://doi.org/10.1097/SLE.0b013e31828b8382.

    Article  Google Scholar 

  18. Akbiyik F, Senel E, Bayram-Kabacam G, Demirkan H, Atayurt H, Tiryaki T. A comparison of polymer clips and endoloop applications for securing the appendiceal stump during laparoscopic surgery in children. Surg Laparosc Endosc Percutaneous Tech. 2011;21(5):349–52. https://doi.org/10.1097/SLE.0b013e31822d68ca.

    Article  Google Scholar 

  19. Delibegovic S. The use of a single Hem-o-lok clip in securing the base of the appendix during laparoscopic appendectomy. J Laparoendosc Adv Surg Tech. 2012;22(1):85–7. https://doi.org/10.1089/lap.2011.0348.

    Article  Google Scholar 

  20. Şimşek OBI, Uludag S, Dal F, Velidedeoğlu K, Pekmezci S. Comparison of endo-loop and polymer locking clip in ligating appendiceal stump during laparoscopic appendicectomy. Eur J Endosc Laparosc Surg. 2014;1:124–7.

    Article  Google Scholar 

  21. Polat YKE. Comparison of intra corporeal knot-tying suture and Hem-o-lok clip for closure of appendix stump in laparoscopic appendectomy: a retrospective study. Firat Med J. 2011;20:107–9.

    Google Scholar 

  22. Jenwitheesuk KCE, Saeseow OT, Thanapaisal C, Punchai S, Paonariang K. Laparoscopic appendectomy: results of a new technique for stump management. J Med Assoc Thai. 2012;95(Suppl 11):7–10.

    Google Scholar 

  23. Klein RD, Jessup G, Ahari F, Connolly RJ, Schwaitzberg SD. Comparison of titanium and absorbable polymeric surgical clips for use in laparoscopic cholecystectomy. Surg Endosc. 1994;8(7):753–8.

    Article  CAS  PubMed  Google Scholar 

  24. Baumert H, Ballaro A, Arroyo C, Kaisary AV, Mulders PF, Knipscheer BC. The use of polymer (Hem-o-lok) clips for management of the renal hilum during laparoscopic nephrectomy. Eur Urol. 2006;49(5):816–9. https://doi.org/10.1016/j.eururo.2005.12.073.

    Article  PubMed  Google Scholar 

  25. Delibegovic S, Iljazovic E, Katica M, Koluh A. Tissue reaction to absorbable endoloop, nonabsorbable titanium staples, and polymer Hem-o-lok clip after laparoscopic appendectomy. JSLS. 2011;15(1):70–6. https://doi.org/10.4293/108680811X13022985131336.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Mannu GS, Sudul MK, Bettencourt-Silva JH, Cumber E, Li F, Clark AB, et al. Closure methods of the appendix stump for complications during laparoscopic appendectomy. Cochrane Database Syst Rev. 2017;11:CD006437. https://doi.org/10.1002/14651858.CD006437.pub3.

    Article  PubMed  Google Scholar 

  27. Wilson M, Maniam P, Ibrahim A, Makaram N, Knight SR, Patil P. Polymeric clips are a quicker and cheaper alternative to endoscopic ligatures for securing the appendiceal stump during laparoscopic appendicectomy. Ann R Coll Surg Engl. 2018. https://doi.org/10.1308/rcsann.2018.0036.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Michael Samuel James Wilson.

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Stephen Robert Knight declares that he has no conflict of interest. Abdulla Ibrahim declares that he has no conflict of interest. Navnit Makaram declares that he has no conflict of interest. Pradeep Patil declares that he has no conflict of interest. Michael Samuel James Wilson declares that he has no conflict of interest.

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Knight, S.R., Ibrahim, A., Makaram, N. et al. The use of polymeric clips in securing the appendiceal stump during laparoscopic appendicectomy: a systematic review. Eur J Trauma Emerg Surg 45, 665–670 (2019). https://doi.org/10.1007/s00068-019-01105-5

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  • DOI: https://doi.org/10.1007/s00068-019-01105-5

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