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Associations between nine candidate genetic polymorphisms with coronary heart disease

A meta-analysis

Zusammenhang zwischen 9 Kandidaten für genetische Polymorphismen und koronarer Herzkrankheit

Metaanalyse

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Abstract

Background

The aim of this study was to obtain a more accurate assessment of the potential association between nine genetic polymorphisms and the risk of coronary heart disease (CHD).

Methods

A literature search was performed in PubMed, Embase, OVID, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies. We analyzed the odds ratios (OR) and 95% confidence intervals (CI) to assess the strength of the associations.

Results

A significant association was found between the PON1 −108C/T polymorphism and CHD risk (TT vs. CC: OR = 1.67, 95% CI = 1.14–2.47, p = 0.009; CT vs. CC: OR = 1.47, 95% CI = 1.17–1.85, p = 0.001; [TT + CT] vs. CC: OR = 1.56, 95% CI = 1.18–2.06, p = 0.002; T allele vs. C allele: OR = 1.28, 95%CI = 1.06–1.54, p = 0.011). There was a significant association between the hOGG1 +1245C/G polymorphism and CHD (GG vs. CC: OR = 2.33, 95% CI: 1.19–4.56, p = 0.014; CG vs. CC: OR = 1.36, 95% CI: 1.01–1.83, p = 0.046; [GG + CG] vs. CC: OR = 1.46, 95% CI: 1.10–1.94, p = 0.010; GG vs. [CC+CG]: OR = 2.11, 95% CI: 1.08–4.10, p = 0.028; G allele vs. C allele: OR = 1.45, 95% CI: 1.14–1.84, p = 0.002). The results also showed a statistically significant association of the SCARB1 +1050C/T polymorphism with CHD (TT vs. CC: OR = 1.30, 95% CI = 1.04–1.62, p = 0.022). Meta-analyses of the other six polymorphisms suggested a lack of any association with CHD risk.

Conclusion

Our results show that the susceptibility to CHD was associated with three polymorphisms: PON1 −108C/T, hOGG1 +1245C/G, and SCARB1 +1050C/T.

Zusammenfassung

Ziel

Ziel der vorliegenden Studie war es, eine genauere Beurteilung des möglichen Zusammenhangs zwischen 9 genetischen Polymorphismen und dem Risiko für eine koronare Herzkrankheit (KHK) zu erhalten.

Methoden

Um geeignete Studien zu finden, wurde eine Literatursuche in den Datenbanken PubMed, Embase, OVID, Web of Science, Wanfang und Chinese National Knowledge Infrastructure (CNKI) durchgeführt. Die Autoren berechneten die Odds Ratio (OR) und das 95%-Konfidenzintervall (95%-KI), um die Stärke des Zusammenhangs zu ermitteln.

Ergebnisse

Es wurde ein signifikanter Zusammenhang zwischen dem PON1−108C/T-Polymorphismus und dem KHK-Risiko festgestellt (TT vs. CC: OR = 1,67; 95%-KI = 1,14–2,47; p = 0,009; CT vs. CC: OR = 1,47; 95%-KI = 1,17–1,85; p = 0,001; [TT + CT] vs. CC: OR = 1,56; 95%-KI = 1,18–2,06; p = 0,002; T‑Allel vs. C‑Allel: OR = 1,28; 95%-KI = 1,06–1,54; p = 0,011). Auch bestand ein signifikanter Zusammenhang zwischen dem hOGG1+1245C/G-Polymorphismus und KHK (GG vs. CC: OR = 2,33; 95%-KI: 1,19–4,56; p = 0,014; CG vs. CC: OR = 1,36; 95%-KI: 1,01–1,83; p = 0,046; [GG + CG] vs. CC: OR = 1,46; 95%-KI: 1,10–1,94; p = 0,010; GG vs. [CC+CG]: OR = 2,11; 95%-KI: 1,08–4,10; p = 0,028; G‑Allel vs. C‑Allel: OR = 1,45; 95%-KI: 1,14–1,84; p = 0,002). Die Ergebnisse zeigten auch einen statistisch signifikanten Zusammenhang des SCARB1+1050C/T-Polymorphismus mit KHK (TT vs. CC: OR = 1,30; 95%-KI = 1,04–1,62; p = 0,022). Metaanalysen der übrigen 6 Polymorphismen ergaben keine Hinweise auf einen Zusammenhang mit dem KHK-Risiko.

Schlussfolgerung

Die vorliegenden Ergebnisse zeigen, dass die Anfälligkeit für eine KHK mit 3 Polymorphismen in Zusammenhang stand: PON1 −108C/T, hOGG1 +1245C/G und SCARB1 +1050C/T.

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Authors and Affiliations

  1. Department of Medical Oncology, Luohe Central Hospital (Luohe First People’s Hospital), Luohe City, Henan Province, China

    Q. Li

  2. Department of Cardiovascular, Heart Center of Henan Province People’s Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou City, Henan Province, China

    Q. Du

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Contributions

Q. Du and Q. Li conceived and designed the experiments. Q. Li performed the experiments. Q. Li and Q. Du analyzed the data.

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Correspondence to Q. Du.

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Q. Li and Q. Du declare that they have no competing interests.

For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.

Caption Electronic Supplementary Material

59_2019_4806_MOESM1_ESM.tif

Figure S1. A. Sensitivity analysis of PON1 -108C/T polymorphism and CHD risk in the overall analysis under homozygote comparison. B. Sensitivity analysis of PON1 -108C/T polymorphism and CHD risk in the overall analysis under heterozygote comparison

59_2019_4806_MOESM2_ESM.tif

Figure S2. A. Sensitivity analysis of PON1 -162G/A polymorphism and CHD risk in the overall analysis under homozygote comparison. B. Sensitivity analysis of PON1 -162G/A polymorphism and CHD risk in the overall analysis under heterozygote comparison

59_2019_4806_MOESM3_ESM.doc

Supplementary Table 1. Results of Newcastle–Ottawa scale (NOS) assessment for the included studies and full electronic search strategy for electronic databases

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Li, Q., Du, Q. Associations between nine candidate genetic polymorphisms with coronary heart disease. Herz 45 (Suppl 1), 15–28 (2020). https://doi.org/10.1007/s00059-019-4806-7

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