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E-selectin gene polymorphism (A561C) and essential hypertension

Meta-analysis in the Chinese population

E-Selectin-Genpolymorphismus (A561C) und essenzielle Hypertonie

Eine Metaanalyse chinesischer Kollektive

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Abstract

Background

The A561C polymorphism of the E-selectin gene (SELE) has been reported to be associated with essential hypertension (EH) in several studies; however, results among these studies were inconsistent. Here, we conducted a meta-analysis to explore the association of the A561C polymorphism with EH.

Methods

Publications were retrieved through searching PubMed, Web of Science, the China National Knowledge Infrastructure (CNKI), China Biological Medicine, and the Wanfang database. Odds ratios (OR) and 95 % confidence intervals (CI) were calculated to estimate the strength of association of A561C with EH. Subgroup analysis was also performed to assess ethnic discrepancies. A total of seven studies comprising 2,127 EH patients and 2,078 controls were analyzed.

Results

In the dominant model analysis, we found significant associations between the A561C polymorphism and EH in all subjects (CC+AC vs. AA, OR = 1.96, 95 %CI 1.57–2.44, P heterogeneity = 0.381), in a Han Chinese subgroup (CC+AC vs. AA, OR = 2.38, 95 %CI 1.73–3.29, P heterogeneity = 0.269), and in non-Han Chinese minorities (CC+AC vs. AA, OR = 1.62, 95 %CI 1.19–2.21, P heterogeneity = 0.84).

Conclusion

The findings suggest that C allele carriers of the SELE gene polymorphism (A561C) might be predisposed to EH in the Chinese population. Further investigations in other ethnic populations should be conducted to verify these findings.

Zusammenfassung

Hintergrund

Zwar wurde in verschiedenen Studien eine Assoziation zwischen A561C-Polymorphismus des E-selectin -Gens (SELE) und essenzieller Hypertonie (EH) postuliert, doch die Ergebnisse zwischen diesen Studien waren nicht konsistent.

Methoden

Wir führten eine Metaanalyse zur Assoziation zwischen dem A561C-Polymorphismus und EH durch. Entsprechende Publikationen wurden PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), China Biological Medicine und der Wanfang Datenbank entnommen. Berechnet wurden Odds Ratios (OR) und 95%-Konfidenzintervalle (KI), um die Stärke des Zusammenhangs von A561C mit EH abzuschätzen. Zur Ermittlung ethnisch bedingter Diskrepanzen wurde eine Subgruppenanalyse durchgeführt. Analysiert wurden 7 Studien mit insgesamt 2127 Patienten mit EH und 2078 Kontrollen.

Ergebnisse

In der Analyse des Hauptmodells fanden sich signifikante Assoziationen zwischen dem A561C-Polymorphismus und einer EH bei allen Probanden (CC+AC vs. AA, OR = 1,96, 95 %-KI: 1,57–2,44, P heterogeneity = 0,381), in einer han-chinesischen Subgruppe (CC+AC vs. AA, OR = 2,38, 95 %-KI: 1,73–3,29, P heterogeneity = 0,269) und bei nicht-han-chinesischen Minderheiten (CC+AC vs. AA, OR = 1,62, 95 %-KI: 1,19–2,21, P heterogeneity = 0,84).

Schlussfolgerung

Dies weist darauf hin, dass das C-Allel des SELE -Genpolymorphismus (A561C) in der chinesischen Bevölkerung für eine EH disponieren könnte. Um diese Ergebnisse zu verifizieren, sollten weitere Studien mit anderen ethnischen Kollektiven durchgeführt werden.

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Compliance with ethical guidelines

Conflict of interest. H. Wu, A. Tan, H. Yang, Y. Gao, H. Li, S. Lu, Y. Hu, X. Tang, and H, Zhang state that there are no conflicts of interest.

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81060029, 81260130), the Guangxi Natural Science Foundation Program (2012GXNSFDA053016), and the Guangxi Foundation for Science Research and Technology Development (GuiKeGong1140003A-21).

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Authors and Affiliations

  1. School of Public Health of Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, China

    Y. Ouyang, H. Wu, X. Tang & H. Zhang

  2. Cancer Hospital of Guangxi Medical University, Nanning, China

    A. Tan

  3. GuangXi Center for Disease Prevention and Control, -, China

    H. Yang

  4. General Practice School of Guangxi Medical University, Nanning, Guangxi, China

    Y. Gao & H. Li

  5. GuangXi Institute for Occupational Disease Prevention and Control, -, China

    S. Lu

  6. Medical Research Center of Guangxi Medical University, Nanning, China

    Y. Hu

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  1. Y. Ouyang
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Correspondence to H. Zhang.

Additional information

Y. Ouyang, H. Wu, and A.Tan contributed equally to this study.

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Ouyang, Y., Wu, H., Tan, A. et al. E-selectin gene polymorphism (A561C) and essential hypertension. Herz 40 (Suppl 2), 197–202 (2015). https://doi.org/10.1007/s00059-014-4122-1

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  • DOI: https://doi.org/10.1007/s00059-014-4122-1

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