Abstract
Mitral regurgitation (MR) is the most frequent valvular heart disease in developed countries. Surgical repair represents the optimal treatment for severe degenerative MR; however, surgical correction of functional MR is controversial. The Euro Heart Survey showed that up to 50 % of patients with severe MR are today denied surgical treatment. Therefore, new transcatheter techniques have been developed to treat MR with less invasive approaches. Currently, the device with the widest clinical use is the MitraClip System. In this scenario, a multidisciplinary team approach is key in providing optimal individually tailored treatment for patients with MR.
Zusammenfassung
Die Mitralklappeninsuffizienz (MI) ist der häufigste Herzklappenfehler in den Industrieländern. Die chirurgische Korrektur stellt die optimale Behandlung für die schwere degenerative MI dar; im Gegensatz dazu ist die chirurgische Korrektur der funktionellen MI umstritten. Der Euro Heart Survey zeigte, dass heute bis zu 50 % der Patienten mit schwerer MI eine chirurgische Behandlung verwehrt bleibt. Deshalb wurden neue Transkathetertechniken entwickelt, um MI minimalinvasiv zu behandeln. Die größte klinische Erfahrung liegt für den Einsatz des MitraClip-Systems vor. In diesem Szenario ist die Falldiskussion in einem interdisziplinären Team der Schlüssel, um die optimale maßgeschneiderte Behandlung für den einzelnen Patienten mit MI zu gewährleisten.
Similar content being viewed by others
References
Nkomo VT et al (2006) Burden of valvular heart diseases: a population-based study. Lancet 368:1005–1011
Ling LH et al (1996) Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med 335:1417–1423
Anyanwu AC, Adams DH (2007) Etiologic classification of degenerative mitral valve disease: Barlow’s disease and fibroelastic deficiency. Semin Thorac Cardiovasc Surg 19:90–96
Yun KL, Miller DC (1991) Mitral valve repair versus replacement. Cardiol Clin 9:315–327
Olson LJ, Subramanian R, Ackermann DM et al (1987) Surgical pathology of the mitral valve: a study of 712 cases spanning 21 years. Mayo Clin Proc 62:22–34
Detaint D et al (2006) Surgical correction of mitral regurgitation in the elderly: outcomes and recent improvements. Circulation 114:265–272
Kang DH, Kim MJ, Kang SJ et al (2006) Mitral valve repair versus revascularization alone in the treatment of ischemic mitral regurgitation. Circulation 114:I499–I503
Braun J, Bax JJ, Versteegh MI et al (2005) Preoperative left ventricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in ischemic mitral regurgitation. Eur J Cardiothorac Surg 27:847–853
Crabtree TD, Bailey MS, Moon MR et al (2008) Recurrent mitral regurgitation and risk factors for early and late mortality after mitral valve repair for functional ischemic mitral regurgitation. Ann Thorac Surg 85:1537–1542
De Bonis M, Taramasso M, Grimaldi A et al (2011) The GeoForm annuloplasty ring for the surgical treatment of functional mitral regurgitation in advanced dilated cardiomyopathy. Eur J Cardiothorac Surg 40:488–495
Mirabel M, Iung B, Baron G et al (2007) What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery? Eur Heart J 28:1358–1365
Argenziano M, Skipper E, Heimansohn D et al (2010) Surgical revision after percutaneous mitral repair with the MitraClip device. Ann Thorac Surg 89:72–80
Feldman T, Foster E, Glower DD et al (2011) Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 364:1395–1406
Feldman T, Kar S, Rinaldi M et al (2009) Percutaneous mitral repair with the MitraClip system safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol 54:686–694
Feldman T, Wasserman HS, Herrmann HC et al (2005) Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST phase I clinical trial. J Am Coll Cardiol 46:2134–2140
George JC, Varghese V, Dangas G, Feldman TE (2011) Percutaneous mitral valve repair: lessons from the EVEREST II (Endovascular Valve Edge-to-Edge REpair Study) and beyond. JACC Cardiovasc Interv 4:825–827
Glower D, Ailawadi G, Argenziano M et al (2012) EVEREST II randomized clinical trial: predictors of mitral valve replacement in de novo surgery or after the MitraClip procedure. J Thorac Cardiovasc Surg 143:S60–S63
Goldberg SL, Feldman T (2010) Percutaneous mitral valve interventions: overview of new approaches. Curr Cardiol Rep 12:404–412
Herrmann HC, Gertz ZM, Silvestry FE et al (2012) Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) randomized trial. J Am Coll Cardiol 59:1312–1319
Herrmann HC, Kar S, Siegel R et al (2009) Effect of percutaneous mitral repair with the MitraClip (R) device on mitral valve area and gradient. EuroIntervention 4:437–442
Herrmann HC, Rohatgi S, Wasserman HS et al (2006) Mitral valve hemodynamic effects of percutaneous edge-to-edge repair with the MitraClip™ device for mitral regurgitation. Catheter Cardiovasc Interv 68:821–828
Ladich E, Michaels MB, Jones RM et al (2011) Pathological healing response of explanted MitraClip devices. Circulation 123:1418–1427
Mauri L, Garg P, Massaro JM et al (2010) The EVEREST II Trial: design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation. Am Heart J 160:23–29
Siegel RJ, Biner S, Rafique AM et al (2011) The acute hemodynamic effects of MitraClip therapy. J Am Coll Cardiol 57:1658–1665
Silvestry FE, Rodriguez LL, Herrmann HC et al (2007) Echocardiographic guidance and assessment of percutaneous repair for mitral regurgitation with the evalve MitraClip: lessons learned from EVEREST I. J Am Soc Echocardiogr 20:1131–1140
Whitlow PL, Feldman T, Pedersen WR et al (2012) Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) high risk study. J Am Coll Cardiol 59:130–139
Tietge WJ, Heer LM de, Hessen MW van et al (2012) Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. Neth Heart J 20:94–101
Ling LH, Enriquez-Sarano M, Seward JB et al (1997) Early surgery in patients with mitral regurgitation due to flail leaflets: a long-term outcome study. Circulation 96:1819–1825
Mohty D, Orzulak TA, Schaff HV et al (2001) Very long-term survival and durability of mitral valve repair for mitral valve prolapse. Circulation 104:I1–I7
David TE, Ivanov J, Armstrong S, Rakowski H (2003) Late outcomes of mitral valve repair for floppy valves: Implications for asymptomatic patients. J Thorac Cardiovasc Surg 125:1143–1152
Gillinov AM, Mihaljevic T, Blackstone EH et al (2010) Should patients with severe degenerative mitral regurgitation delay surgery until symptoms develop? Ann Thorac Surg 90:481–488
Gillinov AM et al (2008) Valve repair versus valve replacement for degenerative mitral valve disease. J Thorac Cardiovasc Surg 135:885–893
Adams DH et al (2006) Large annuloplasty rings facilitate mitral valve repair in Barlow’s disease. Ann Thorac Surg 82:2096–2100
Gammie JS, Bartlett ST, Griffith BP (2009) Small-incision mitral valve repair: safe, durable, and approaching perfection. Ann Surg 250:409–415
Flameng W, Herijjers P, Bogaerts K (2003) Recurrence of mitral valve regurgitation after mitral valve repair in degenerative valve disease. Circulation 107:1609–1613
Bolling SF, Li S, O’Brien SM et al (2010) Predictors of mitral valve repair: clinical and surgeon factors. Ann Thorac Surg 90:1904–1911
Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic Surgery (EACTS), Vahanian A et al (2012) Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 33:2451–2496
Gammie JS et al (2007) Influence of hospital procedural volume on care process and mortality for patients undergoing elective surgery for mitral regurgitation. Circulation 115:881–887
Savage EB, Ferguson TB Jr, DiSesa VJ (2003) Use of mitral valve repair: analysis of contemporary United States experience reported to the Society of Thoracic Surgeons National Cardiac Database. Ann Thorac Surg 75:820–825
Braunberger E et al (2001) Very long-term results (more than 20 years) of valve repair with Carpentier’s techniques in nonrheumatic mitral valve insufficiency. Circulation 104:I8–I11
David TE, Armstrong S, McCrindle BW, Manlhiot C (2013) Late outcomes of mitral valve repair for mitral regurgitation due to degenerative disease. Circulation (Epub ahead of print)
De Bonis M, Lapenna E, Lorusso R et al (2012) Very long-term results (up to 17 years) with the double-orifice mitral valve repair combined with ring annuloplasty for degenerative mitral regurgitation. J Thorac Cardiovasc Surg 144:1019–1024
Montant P et al (2009) Long-term survival in asymptomatic patients with severe degenerative mitral regurgitation: a propensity score-based comparison between an early surgical strategy and a conservative treatment approach. J Thorac Cardiovasc Surg 138:1339–1348
De Bonis M, Bolling S (2013) Mitral valve surgery: wait and see vs. early operation. Eur Heart J 34:13–19
Ling LH, Enriquez-Sarano M, Seward JB et al (1997) Early surgery in patients with mitral regurgitation due to flail leaflets: a long term outcome study. Circulation 96:1819–1825
De Bonis M, Maisano F, La Canna G, Alfieri O (2012) Treatment and management of mitral regurgitation. Nat Rev Cardiol 9:133–146
Jung B, Baron G, Butchart EG et al (2003) A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J 24:1231–1243
O’Brien SM, Shahian DM, Filardo G et al (2009) The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2—isolated valve surgery. Ann Thorac Surg 88:S23–S42
Mehta RH, Eagle KA, Coombs LP et al (2002) Influence of age on outcomes in patients undergoing mitral valve replacement. Ann Thorac Surg 74:1459–1467
Badhwar V, Peterson ED, Jacobs JP et al (2012) Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007. Ann Thorac Surg 94:1870–1877
Seeburger J, Falk V, Garbade J et al (2012) Mitral valve surgical procedures in the elderly. Ann Thorac Surg 94:1999–2003
Chikwe J, Goldstone AB, Passage J et al (2011) A propensity score-adjusted retrospective comparison of early and mid-term results of mitral valve repair versus replacement in octogenarians. Eur Heart J 32:618–626
Maisano F, Viganò G, Calabrese C et al (2009) Quality of life of elderly patients following valve surgery for chronic organic mitral regurgitation. Eur J Cardiothorac Surg 36:261–266
Schnellinger W (2012) Analysis of six months outcomes by mitral regurgitation etiology in the ACCESS-EUROPE study. EuroPCR, Paris
Ussia GP, Cammalleri V, Sarkar K et al (2012) Quality of life following percutaneous mitral valve repair with the MitraClip System. Int J Cardiol 155:194–200
Grigioni F, Enriquez-Sarano M, Zehr KJ et al (2001) Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 103:1759–1764
Flynn M et al (2009) Regional wall motion abnormalities and scarring in severe functional ischemic mitral regurgitation: a pilot cardiovascular magnetic resonance imaging study. J Thorac Cardiovasc Surg 137:1063–1070
Acker MA, Bolling S, Shemin R et al (2006) Mitral valve surgery in heart failure: insights from the Acorn Clinical Trial. J Thorac Cardiovasc Surg 132:568–577
Bax JJ, Braun J, Somer ST et al (2004) Restrictive annuloplasty and coronary revascularization in ischemic mitral regurgitation results in reverse left ventricular remodeling. Circulation 110:II103–II108
De Bonis M, Lapenna E, Verzini A et al (2008) Recurrence of mitral regurgitation parallels the absence of left ventricular reverse remodeling after mitral repair in advanced dilated cardiomyopathy. Ann Thorac Surg 85:932–939
Wu AH et al (2005) Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction. J Am Coll Cardiol 45:381–387
Mihaljevic T et al (2007) Impact of mitral valve annuloplasty combined with revascularization in patients with functional ischemic mitral regurgitation. J Am Coll Cardiol 49:2191–2201
Bolling SF et al (1995) Early outcome of mitral valve reconstruction in patients with end-stage cardiomyopathy. J Thorac Cardiovasc Surg 109:676–682
Silberman S et al (2009) Repair of ischemic mitral regurgitation: comparison between flexible and rigid annuloplasty rings. Ann Thorac Surg 87:1721–1726
Alfieri O, De Bonis M (2010) Mitral valve repair for functional mitral regurgitation: is annuloplasty alone enough? Curr Opin Cardiol 25:114–118
McGee EC et al (2004) Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation. J Thorac Cardiovasc Surg 128:916–924
Hung J et al (2004) Mechanism of recurrent ischemic mitral regurgitation after annuloplasty: continued LV remodeling as a moving target. Circulation 110:II85–II90
De Bonis M, Lapenna E, La Canna G et al (2005) Mitral valve repair for functional mitral regurgitation in end-stage dilated cardiomyopathy: role of the “edge-to-edge” technique. Circulation 112:I402–I408
Tamburino C, Ussia GP, Maisano F et al (2010) Percutaneous mitral valve repair with the MitraClip system: acute results from a real world setting. Eur Heart J 31:1382–1389
Franzen O, Heyden J van der, Baldus S et al (2011) MitraClip® therapy in patients with end-stage systolic heart failure. Eur J Heart Fail 13:569–576
Pleger ST, Schulz-Schönhagen M, Geis N et al (2013) One year clinical efficacy and reverse cardiac remodelling in patients with severe mitral regurgitation and reduced ejection fraction after MitraClip(C) implantation. Eur J Heart Fail (Epub ahead of print)
Maisano F (2010) European percutaneous mitral valve therapy experience: acute results in the first 1000 patients. Data from the European ACCESS Registry: what patients have been treated in Europe? Presented at TCT 2010
Schillinger W (2012) ACCESS-EUROPE—an observational study of the MitraClip® System in Europe. Presented at ECS Meeting 2012
Baldus S, Schillinger W, Franzen O et al (2012) MitraClip therapy in daily clinical practice: initial results from the German transcatheter mitral valve interventions (TRAMI) registry. Eur J Heart Fail 14:1050–1055
Sürder D, Pedrazzini G, Gaemperli O et al (2013) Predictors for efficacy of percutaneous mitral valve repair using the MitraClip system: the results of the MitraSwiss registry. Heart (Epub ahead of print)
Grasso C, Capodanno D, Scandura S et al (2013) One- and twelve-month safety and efficacy outcomes of patients undergoing edge-to-edge percutaneous mitral valve repair (from the GRASP Registry). Am J Cardiol (Epub ahead of print)
Taramasso M, Denti P, Buzzatti N et al (2012) Mitraclip therapy and surgical mitral repair in patients with moderate to severe left ventricular failure causing functional mitral regurgitation: a single-centre experience. Eur J Cardiothorac Surg 42:920–926
Conradi L, Treede H, Rudolph V et al (2013) Surgical or percutaneous mitral valve repair for secondary mitral regurgitation: comparison of patient characteristics and clinical outcomes. Eur J Cardiothorac Surg (Epub ahead of print)
Conflict of interest
On behalf of all authors, the corresponding author states that the following: Dr. Maisano is consultant for Abbot Vascular.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Taramasso, M., Buzzatti, N., La Canna, G. et al. Interventional vs. surgical mitral valve therapy. Herz 38, 460–466 (2013). https://doi.org/10.1007/s00059-013-3859-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00059-013-3859-2
Keywords
- Mitral regurgitation
- Surgical mitral repair
- Percutaneous mitral repair
- MitraClip System
- Multidisciplinary approach