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Percutaneous Mitral Valve Interventions: Overview of New Approaches

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Abstract

The percutaneous management of valvular heart disease has recently been receiving a great deal of interest as an area of great potential. Innovative technologies are now being developed to treat mitral regurgitation. Although there are established surgical techniques for treating organic mitral regurgitation, the surgical management of functional mitral regurgitation remains controversial, and such patients have a poor prognosis. Therefore, a percutaneous treatment for functional mitral regurgitation holds great clinical potential. Having a nonsurgical approach available may be attractive to patients with organic mitral valve regurgitation as well. Several approaches and devices have been designed to treat specifically functional mitral regurgitation, and some of these have been applied to humans in early-stage evaluations. The MitraClip device (Abbott Laboratories, Abbott Park, IL) has been used to treat both functional and degenerative mitral valve regurgitation and has been compared to surgery in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study II) randomized trial. Although the field of percutaneous management of mitral regurgitation is at an early stage, it has been demonstrated that percutaneous approaches can reduce mitral regurgitation, suggesting there is a great deal of potential for clinical benefit to patients with mitral regurgitation.

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Abbreviations

AMADEUS:

CARILLON Mitral Annuloplasty Device European Union Study

EVEREST:

Endovascular Valve Edge-to-Edge Repair Study

EVOLUTION:

Clinical Evaluation of the Edwards Lifesciences Percutaneous Mitral Annuloplasty System for the Treatment of Mitral Regurgitation

TITAN:

Treatment of Functional Mitral Regurgitation with Percutaneous Annuloplasty

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Disclosure

Dr. Steven L. Goldberg has received salary support and has stock options with Cardiac Dimensions, Inc. Dr. Ted Feldman has received research grants from Abbott Laboratories and Edwards Lifesciences, and has been a consultant for Abbott Laboratories and Edwards Lifesciences.

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Authors and Affiliations

  1. University of Washington Medical Center, Seattle, WA, USA

    Steven L. Goldberg

  2. Cardiac Dimensions, Inc., Kirkland, WA, USA

    Steven L. Goldberg

  3. Evanston Hospital, Evanston, IL, USA

    Ted Feldman

Authors
  1. Steven L. Goldberg
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  2. Ted Feldman
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Correspondence to Steven L. Goldberg.

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Goldberg, S.L., Feldman, T. Percutaneous Mitral Valve Interventions: Overview of New Approaches. Curr Cardiol Rep 12, 404–412 (2010). https://doi.org/10.1007/s11886-010-0130-9

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