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Diagnostik und Screening

Wissenschaft heute – Standard morgen, Koloproktologie UPDATE 2015

Diagnostics and screening

Today’s science – tomorrow’s standard, coloproctology UPDATE 2015

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coloproctology Aims and scope

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Weiterführende Literatur

  1. Hundt S, Haug U, Brenner H (2009) Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med 150:162–169

    Article  PubMed  Google Scholar 

  2. Callistri D, Rengucci C, Gardini AC et al (2010) Fecal DNA for noninvasive diagnosis of colorectal cancer in immunochemical fecal occult blood test-positive individuals. Cancer Epidemiol Biomarkers Prev 19:2647–2654

    Article  Google Scholar 

  3. Paimela H, Malila N, Palva T et al (2010) Early detection of colorectal cancer with faecal occult blood test screening. Br J Surg 97:1567–1571

    Article  CAS  PubMed  Google Scholar 

  4. Park DI, Ryu S, Kim YH et al (2010) Comparison of guaiac-based and quantitative immunochemical fecal occult blood testing in a population at average risk undergoing colorectal cancer screening. Am J Gastroenterol 105:2017–2025

    Article  PubMed  Google Scholar 

  5. Zhu MM, Xu XT, Nie F et al (2010) Comparison of immonochemical and guaiac-based fecal occult blood testing screening and surveillance for advanced colorectal neoplasms: A meta-analysis. J Dig Dis 11:148–160

    Article  PubMed  Google Scholar 

  6. Miller S, Steele S (2012) Novel molecular screening approaches in colorectal cancer. J Surg Oncol 105:459–467

    Article  CAS  PubMed  Google Scholar 

  7. AWMF (2014) Leitlinie „kolorektales Karzinom“. http://www.awmf.org/uploads/tx_szleitlinien/021-007OLl_S3_KRK_2014-08.pdf. Zugegriffen: Juli 2015

    Google Scholar 

  8. Raginel T, Puvinel J, Ferrand O, Bouvier V, Levillain R, Ruiz A, Lantieri O, Launoy G, Guittet (2013) A population-based comparison of immunochemical fecal occult blood tests for colorectal cancer screening. Gastroenterology 144:918–925

    Article  CAS  PubMed  Google Scholar 

  9. Tinmouth J, Lansdorp-Vogelaar I, Allison JE (2015) Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know. Gut 64:1327–1337

    Article  PubMed  Google Scholar 

  10. Kumar Y, Tapuria N, Kirmani N, Davidson BR (2007) Tumour M2-pyruvate kinase: a gastrointestinal cancer marker. Eur J Gastroenterol Hepatol 19:265–276

    Article  CAS  PubMed  Google Scholar 

  11. Haug U, Hundt S, Brenner H (2008) Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study. Br J Cancer 99:133–135

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Diehl F, Schmidt K, Durkee KH et al (2008) Analysis of mutations in DANN isolated from plasma and stool of colorectal cancer patients. Gastroenterology 135:489–498

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Ahlquist DA, Sargent DJ, Loprinzi CI et al (2008) Stool DAN and occult blood testing for screen detction of colorectal neoplsia. Ann Intern Med 149:441–450

    Article  PubMed Central  PubMed  Google Scholar 

  14. Gupta AK, Brenner DE, Turgeon DK (2008) Early detection of colon cancer: new tests on the horizon. Mol Diagn Ther 12:77–85

    Article  PubMed  Google Scholar 

  15. Möslein G, Schneider C, Theilheimer A et al (2010) Evaluierung der statistischen Kennwerte verschiedener kommerziell erhältlicher Stuhltests. Dtsch Med Wochenschr 135:557–562

    Article  PubMed  Google Scholar 

  16. Li R, Liu J, Xue H, Huang G (2012) Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis. Int J Cancer 131:1837–1845

    Article  CAS  PubMed  Google Scholar 

  17. Altomare DF, Di Lena M, Porcelli F, Trizio L, Travaglio E, Tutino M, Dragonieri S, Memeo V, de Gennaro G (2013) Exhaled volatile organic compounds identify patients with colorectal cancer. Br J Surg 100:144–150

    Article  CAS  PubMed  Google Scholar 

  18. Diehl F, Schmidt K, Durkee KH et al (2008) Analysis of mutations in DANN isolated from plasma and stool of colorectal cancer patients. Gastroenterology 135:489–498

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Ahlquist DA, Sargent DJ, Loprinzi CI et al (2008) Stool DAN and occult blood testing for screen detction of colorectal neoplsia. Ann Intern Med 149:441–450

    Article  PubMed Central  PubMed  Google Scholar 

  20. Gupta AK, Brenner DE, Turgeon DK (2008) Early detection of colon cancer: new tests on the horizon. Mol Diagn Ther 12:77–85

    Article  PubMed  Google Scholar 

  21. deVos T, Tetzner R, Model F et al (2009) Circulation methylated Sept9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 55(7):1337–1347

    Article  CAS  PubMed  Google Scholar 

  22. Creeden J, Junker F, Vogel-Ziebolz S, Rex D (2011) Serum Tests for colorectal cancer screening. Mol Diagn Ther 15:129–141

    Article  PubMed  Google Scholar 

  23. Miller S, Steele S (2012) Novel molecular screening approaches in colorectal cancer. J Surg Oncol 105:459–467

    Article  CAS  PubMed  Google Scholar 

  24. Newton K, Newman W, Hill J (2012) Review of biomarkers in colorectal cancer. Colorectal Dis 14:3–17

    Article  CAS  PubMed  Google Scholar 

  25. Hassan C, Pickhardt PJ, Rex DK (2010) Performance improvements of imaging-based screening tests. Best Pract Res Clin Gastroenterol 24:493–507

    Article  PubMed  Google Scholar 

  26. Ozel B, Pickhardt PJ, Kim DH et al (2010) Accuracy of routine nontargeted CT without colonography technique for the detection of large colorectal polyps and cancer. Dis Colon Rectum 53:6

    Article  Google Scholar 

  27. Pickhardt PJ, Hain KS, Kim DH et al (2010) Low rates of cancer or high-grade dysplasia in colorectal polyps collected from computed tomography colonography screening. Clin Gastroenterol Hepatol 8:610–615

    Article  PubMed  Google Scholar 

  28. Pickhardt PJ, Kim DH (2010) Performance of CT Colonography for detecting small, diminutive, and flat polyps. Gastrointest Endosc Clin N Am 20:209–226

    Article  PubMed  Google Scholar 

  29. Dighe S, Blake H, Koh MD et al (2010) Accuracy of multidetector computed tomography in identifying poor prognostic factors in colonic cancer. Br J Surg 97:1407–1415

    Article  CAS  PubMed  Google Scholar 

  30. Pickhardt PJ, Wise SM, Kim DH (2010) Positive predictive value for polyps detected at screening CT colonography. Eur Radiol 20:1651–1656

    Article  PubMed  Google Scholar 

  31. Sabanli M, Balasingam A, Bailey W et al (2010) Computed tomographic colonography in the diagnosis of colorectal cancer. Br J Surg 97:1291–1294

    Article  CAS  PubMed  Google Scholar 

  32. Pickhardt P, Kim DH, Meiners RJ et al (2010) Colorectal and extracolonic cancer detected at screening CT colonography in 10.286 asymptomatic adults. Radiology 255(1):83–88

    Article  PubMed  Google Scholar 

  33. Stoop E, de Haan M, de Wijkerslooth T et al (2012) Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet 13:55–64

    Article  PubMed  Google Scholar 

  34. Yee J, Weinstein S, Morgan T, Alore P, Aslam R (2013) Advances in CT colonography for colorectal cancer screening and diagnosis. J Cancer 4:200–209

    Article  PubMed Central  PubMed  Google Scholar 

  35. Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, Yao G, Kay C, Burling D, Faiz O, Teare J, Lilford RJ, Morton D, Wardle J, Halligan S (2013) SIGGAR investigators. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicenter randomised trial. Lancet 381:1194–1202

    Article  PubMed  Google Scholar 

  36. Halligan S, Wooldrage K, Dadswell E, Kralj-Hans I, von Wagner C, Edwards R, Yao G, Kay C, Burling D, Faiz O, Teare J, Lilford RJ, Morton D, Wardle J, Atkin W (2013) SIGGAR investigators. Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomized trial. Lancet 381:1185–1193

    Article  PubMed  Google Scholar 

  37. Simons PC, Van Steenbergen LN, De Witte MT, Janssen-Heijnen ML (2013) Miss rate of colorectal cancer at CT colonography in average-risk symptomatic patients. Eur Radiol 23:908–913

    Article  CAS  PubMed  Google Scholar 

  38. Albert JM (2013) Radiation risk from CT: implications for cancer screening. Am J Roentgenol 201:W81–W87

    Article  Google Scholar 

  39. MERCURY Study Group (2006) Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 333:779–785

    Article  PubMed Central  Google Scholar 

  40. Beets-Tan RG, Beets GL, Vliegen RF, Kessels AG, van Boven H, de Bruine A et al (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357:497–504

    Article  CAS  PubMed  Google Scholar 

  41. Martling A, Holm T, Bremmer S, Lindholm J, Cedermark B, Blomqvist L (2003) Prognostic value of preoperative magnetic resonance imaging of the pelvis in rectal cancer. Br J Surg 90:1422–1428

    Article  CAS  PubMed  Google Scholar 

  42. MERCURY Study Group (2007) Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer. Radiology 243:132–139

    Article  Google Scholar 

  43. Taylor FG, Swift RI, Blomqvist L, Brown G (2008) A systematic approach of the interpretation of preoperative staging MRI for rectal cancer. Am J Roentgenol 191:1827–1835

    Article  Google Scholar 

  44. Taylor F, Quirke P, Heald R et al (2011) Preoperative high-resolution MRI can identify good prognosis stage I, II and III rectal cancer best managed by surgery alone. A prospective, multicenter, European Study. Ann Surg 253:711–719

    Article  PubMed  Google Scholar 

  45. Taylor F, Quirke P, Heald R et al (2011) One millimetre is the safe cut-off for MRI predection of surgical margin status in rectal cancer. Br J Surg 98:872–879

    Article  CAS  PubMed  Google Scholar 

  46. Al-Sukhni E, Milot L, Fruitman M et al (2012) Diagnostic accuracy of MRI assessment of T category, lymph node metastases, and circumferential margin involvement in patients with rectal cancer: a systematic review and meta-analysis. Ann Surg Oncol 19:2212–2223

    Article  PubMed  Google Scholar 

  47. Park JS, Jang YJ, Choi GS, Park SY, Kim HJ, Kang H, Cho SH (2014) Accuracy of oreoperative MRI in predicting pathology stage in rectal cancers: node-for-node matched histopathology validation of MRI features. Dis Colon Rectum 57:32–38

    Article  PubMed  Google Scholar 

  48. Allen SD, Padhani AR, Dzik-Jurasz AS et al (2007) Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy. Am J Roentgenol 188:442–451

    Article  Google Scholar 

  49. Chen CC, Lee RC, Lin JK et al (2005) How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis Colon Rectum 48:722–728

    Article  PubMed  Google Scholar 

  50. Will O, Purkayastha S, Chan C et al (2006) Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a metaanalysis. Lancet Oncol 7:52–60

    Article  PubMed  Google Scholar 

  51. Dresen RC, Beets GL, Rutten H et al (2009) MRI for restaging after neoadjuvant radiochemotherapy in locally advanced rectal cancer. Part I: Are we able to predict tumor confined to the rectal wall? Radiology 252:71–80

    Article  PubMed  Google Scholar 

  52. Bujko K, Sopylo R, Kepka L (2007) Local excision after radio(chemo)therapy for rectal cancer: is it safe? Clin Oncol (R Coll Radiol) 19:693–700

    Article  CAS  Google Scholar 

  53. Shihab OC, Quirke P, Heald RJ et al (2010) Magnetic resonance imaging-detected lymph nodes close to the mesorectal fascia are rarely a cause of margin involvement after total mesorectal excision. Br J Surg 97:1431–1436

    Article  CAS  PubMed  Google Scholar 

  54. Engelen S, Beets-Tan R, Lahaye M et al (2010) MRI after chemoradiotherapy of rectal cancer: A useful tool to select patients for local excision. Dis Colon Rectum 53:979–986

    Article  PubMed  Google Scholar 

  55. Lambregts D, Maas M, Bakers F et al (2011) Long-term follow-up features on rectal MRI during a wait-and-see approach after clinical complete response in patients with rectal cancer treated with chemoradiotherapy. Dis Colon Rectum 54:1521–1528

    Article  PubMed  Google Scholar 

  56. Intven M, Reerink O, Philippens ME (2013) Diffusion-weighted MRI in locally advanced rectal cancer: pathological response prediction after neo-adjuvant radiochemotherapy. Strahlenther Onkol 189:117–122

    Article  CAS  PubMed  Google Scholar 

  57. Wu LM, Zhu J, Hu J, Yin Y, Gu HY, Hua J, Chen J, Xu JR (2013) Is there a benefit in using magnetic resonance imaging in the prediction of preoperative neoadjuvant therapy response in locally advanced rectal cancer? Int J Colorectal Dis 28:1225–1238

    Article  PubMed  Google Scholar 

  58. Bokemeyer B, Bock H, Hüppe D et al (2009) Screening colonoscopy for colorectal cancer prevention: results from am German online registry on 269.000 cases. Eur J Gastroenterol Hepatol 21:650–655

    Article  PubMed  Google Scholar 

  59. Brenner H, Hoffmeister M, Brenner G et al (2009) Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: Estimates based on 1.875.708 screening colonoscopies. Eur J Cancer 45:2027–2033

    Article  PubMed  Google Scholar 

  60. Klug S (2010) Koloskopiescreening in Deutschland: Eine Erfolgsgeschichte? Dtsch Arztebl Int 107:751–752

    PubMed Central  PubMed  Google Scholar 

  61. Altenhofen L (2009) Darmkrebs trotz Screeningangebot. Dtsch Arztebl Int 106:193–194

    PubMed Central  PubMed  Google Scholar 

  62. Castiglione G (2010) Screening for colorectal cancer: flexible sigmoidoscopy and faecal occult blood immunochemical testing. Which test is superior? Gut 59:9–10

    Article  PubMed  Google Scholar 

  63. Brenner H, Haug U, Arndt V et al (2010) Low risk of colorectal cancer and advanced adenomas more than 10 Years after negative colonoscopy. Gastroenterology 138:870–876

    Article  PubMed  Google Scholar 

  64. Brenner H, Altenhofen L, Hoffmeister M (2010) Zwischenbilanz der Früherkennungskoloskopie nach acht Jahren: Eine Hochrechnung und erste Ergebnisse. Dtsch Arztebl Int 107:753–759

    PubMed Central  PubMed  Google Scholar 

  65. Brenner H, Chang-Claude J, Seiler CM et al (2006) Does a negative screening colonoscopy ever need to be repeated? Gut 55:1145–1150

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  66. Johnson PM, Gallinger S, McLeod RS (2006) Surveillance colonoscopy in individuals at risk for hereditary nonpolyposis colorectal cancer: an evidence-based review. Dis Colon Rectum 49:80–93

    Article  PubMed  Google Scholar 

  67. Imperiale T, Glowinski E, Lin-Cooper C et al (2008) Five-year risk of colorectal neoplasia after negative screening colonoscopy. N Engl J Med 359:1218–1224

    Article  CAS  PubMed  Google Scholar 

  68. Singh H, Turner D, Xue L et al (2006) Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies. JAMA 295:2366–2373

    Article  CAS  PubMed  Google Scholar 

  69. Pox C, Altenhofen L, Brenner H et al (2012) Efficacy of a nationwide screening colonoscopy program for colorectal cancer. Gastroenterology 142:1460–1467

    Article  PubMed  Google Scholar 

  70. Denis B, Gendre I, Sauleau EA, Lacroute J, Perrin P (2013) Harms of colonoscopy in a colorectal cancer screening programme with faecal occult blood test: A population-based cohort study. Dig Liver Dis 45:474–480

    Article  PubMed  Google Scholar 

  71. Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BA, Fuchs CS, Giovannucci E, Ogino S, Chan AT (2013) Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med 369:1095–1105

    Article  CAS  PubMed  Google Scholar 

  72. Black C, Hagstrom D, Welch H (2002) All-cause mortality in randomized trials of cancer screening. J Natl Cancer Inst 94:167–173

    Article  PubMed  Google Scholar 

  73. Moayyedi P, Achkar E (2006) Does fecal occult blood testing really reduce mortality? A reanalysis of systematic review data. Am J Gastroenterol 101:380–384

    Article  PubMed  Google Scholar 

  74. Hewiston P, Glasziou P, Watson E et al (2008) Cochrane systematic review of colorectal cancer screening using the fecal occult test (Hemoccult): an update. Am J Gastroenterol 103:1541–1549

    Article  Google Scholar 

  75. Lindholm E, Brevinge H, Haglind E (2008) Survival benefit in a randomized clinical trial of faecal occult blood screening for colorectal cancer. Br J Surg 95:1029–1036

    Article  CAS  PubMed  Google Scholar 

  76. Sigurdsson JA, Getz L, Sjönell G, Vainiomäki P, Brodersen J (2013) Marginal public health gain of screening for colorectal cancer: modelling study, based on WHO and national databases in the Nordic countries. J Eval Clin Pract 19:400–407

    Article  PubMed Central  PubMed  Google Scholar 

  77. Shaukat A, Mongin SJ, Geisser MS, Lederle FA, Bond JH, Mandel JS, Church TR (2013) Long-term mortality after screening for colorectal cancer. N Engl J Med 369:1106–1114

    Article  CAS  PubMed  Google Scholar 

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Dieses Manuskript basiert auf einem Vortrag gehalten auf dem „Koloproktologie UPDATE 2015“ am 19.11.2015 in Hannover. Die Zusammenfassungen der Studien sind Übersetzungen der englischen Abstracts der Originalpublikation.

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Sailer, M. Diagnostik und Screening. coloproctology 38, 22–36 (2016). https://doi.org/10.1007/s00053-015-0060-5

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