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Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities

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Abstract

Myricetin is a common plant-derived flavonoid and exhibits a wide range of activities. However, myricetin also exhibits substantial limitations, such as its poor water-solubility and low stability in body when it was administrated orally. To solve these problems, a series of myricetin derivatives with different disaccharide groups were designed, synthesized and evaluated their hypoglycemic activities. All synthesized compounds displayed significant α-glucosidase inhibitory activity in comparison with acarbose in vitro, which indicated that myricetin derivatives with different disaccharide groups had good hypoglycemic activity and could be further developed as hypoglycemic drugs.

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All data generated or analysed during this study are included in this published article and its supplementary information files.

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Author contributions

FL, CY, and LZ synthesized compounds and contributed to the design and characterization of compounds. FL and WL performed to the preparation of the manuscript. FL and CY performed the biological assay. WL supervised all phases of the study. All authors read and approved the article.

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Authors and Affiliations

  1. Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization, Weifang University of Science and Technology, Weifang, 262700, China

    Feng Li & Wenbao Li

  2. School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China

    Chong Yang, Liang Zhang & Wenbao Li

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  1. Feng Li
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  2. Chong Yang
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  4. Wenbao Li
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Correspondence to Feng Li or Wenbao Li.

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Li, F., Yang, C., Zhang, L. et al. Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities. Med Chem Res 32, 76–84 (2023). https://doi.org/10.1007/s00044-022-02992-x

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  • DOI: https://doi.org/10.1007/s00044-022-02992-x

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