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Antifungal activity of aminoalcohols and diamines against dermatophytes and yeast

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Abstract

Dermatomycoses are infections caused by fungi and yeasts and the drug treatment is considered expensive and extensive. Researchers are synthesizing new organic compounds in order to obtain more effective molecules that provide reduced adverse effects. Our research group has synthesized and evaluated the biological activities of aminoalcohol and diamine derivatives, which were considered active against human pathogenic fungi. Therefore, the objective of this study was to evaluate the in vitro antifungal activity of aminoalcohols and diamine derivatives against fungi and yeasts that cause dermatomycoses. The minimum inhibitory concentrations (MICs) and the minimum fungicidal concentration (MFC) of aminoalcohol (1–4) and diamine (5–13) derivatives was determined against Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum, and Candida albicans according to protocols from the Clinical and Laboratory Standards Institute. All molecules exhibited fungicidal activity against the evaluated fungal strains, with the MIC and MFC ranging between 0.12 and 1000 μg/mL for filamentous fungi and 0.6 and 1250 μg/mL for yeasts. The best activity was attributed to diamines compared to aminoalcohols, with an emphasis on molecules 6 and 7. These results demonstrate the antifungal potential of the evaluated aminoalcohols and diamines against the four primary fungal species that cause dermatomycoses.

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Acknowledgements

This research was supported by Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq), Research Support Foundation of the State of Minas Gerais (FAPEMIG), Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ-E-26/202.447/2019), and Pro-Rectorate of Graduate Studies and Research at the Federal University of Juiz de Fora (PROPESQ/UFJF).

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  1. Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Juiz de Fora, MG, 36036-330, Brazil

    César A. Caneschi, Renata P. do Carmo, Francislene J. Martins & Nádia R. B. Raposo

  2. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Juiz de Fora, MG, 36036-330, Brazil

    Bruno A. de Oliveira, Angelina M. de Almeida & Mauro V. de Almeida

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  1. César A. Caneschi
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  3. Angelina M. de Almeida
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Caneschi, C.A., de Oliveira, B.A., de Almeida, A.M. et al. Antifungal activity of aminoalcohols and diamines against dermatophytes and yeast. Med Chem Res 29, 2164–2169 (2020). https://doi.org/10.1007/s00044-020-02636-y

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