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Synthesis and biological evaluation of novel triazolyl 4-anilinoquinazolines as anticancer agents

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Abstract

The synthesis of novel triazolyl 4-anilinoquinazolines in five sequential synthetic steps via copper-catalyzed click chemistry and their anticancer biological evaluation is described.

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Acknowledgements

This work was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, under grant number G-203-141-1436. We, therefore, thank DSR for financial support.

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Authors and Affiliations

  1. King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Saudi Arabia

    Hani Mutlak A. Hassan, Iuliana Denetiu & Mohd Rehan

  2. Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah, 21589, Saudi Arabia

    Salman A. Khan

  3. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Saudi Arabia

    Kaltoom Sakkaf

  4. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Saudi Arabia

    Kalamegam Gauthaman

Authors
  1. Hani Mutlak A. Hassan
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  2. Iuliana Denetiu
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  3. Salman A. Khan
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  4. Mohd Rehan
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  5. Kaltoom Sakkaf
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  6. Kalamegam Gauthaman
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Correspondence to Hani Mutlak A. Hassan.

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Hassan, H.M.A., Denetiu, I., Khan, S.A. et al. Synthesis and biological evaluation of novel triazolyl 4-anilinoquinazolines as anticancer agents. Med Chem Res 28, 1766–1772 (2019). https://doi.org/10.1007/s00044-019-02413-6

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  • DOI: https://doi.org/10.1007/s00044-019-02413-6

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