Synthesis of novel 5-methyl pyrazol-3-one derivatives and their in vitro cytotoxic evaluation

Abstract

In this study, new compounds of pyrazolone heterocyclic derivatives were synthesized by reaction of 5-methyl pyrazol-3-one with appropriate substituted aromatic aldehydes to obtain various substituted 4-benzylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one (2a–j), which on treatment with benzyl chloride afforded the compound (3a–j). The synthesized compounds were evaluated for their in vitro cytotoxic activity by two models—Brine shrimp lethality bioassay and SRB assay.

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Acknowledgments

The authors are thankful to Head of the Department, Pharmaceutical Chemistry; and Principal, S.M.B.T College of Pharmacy, Nashik (MS), India for providing necessary facilities to carry out this research work.

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Correspondence to Shweta S. Bule.

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Dube, P.N., Bule, S.S., Ushir, Y.V. et al. Synthesis of novel 5-methyl pyrazol-3-one derivatives and their in vitro cytotoxic evaluation. Med Chem Res 24, 1070–1076 (2015). https://doi.org/10.1007/s00044-014-1201-z

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Keywords

  • Pyrazolone
  • Cytotoxic
  • Brine shrimp lethality
  • SRB assay