Abstract
A series of new 6-[(N 1-aryl-1H-1,2,3-triazol-4-yl)methyl]-6H-indolo[2,3-b]quinoxa-line derivatives 7a i–ix and 7b i–vi is synthesized by a simple multi-step protocol starting from isatin 1a or 5-fluoroisatin 1b. These compounds are screened against lung (A-549), cervical (HeLa), and prostate (DU-145) human cancer cell lines to evaluate their cytotoxic effect. Of all the compounds tested, five compounds showed moderate cytotoxicity against human reproductive organ cell lines, while others exhibited lower cytotoxicity against different human cancer cell lines. An elegant synthesis of these complex molecules and their cytotoxicity data are presented.
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Acknowledgments
A. Sreenivas, K. Jayaram Reddy, K. Satish, and K. Koteswara Rao are thankful to CSIR, New Delhi, for providing Senior Research Fellowship. Ramanujan Fellowship to K. Srigiridhar from DST, India, is greatly acknowledged.
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Avula, S., Komsani, J.R., Koppireddi, S. et al. Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives. Med Chem Res 22, 3712–3718 (2013). https://doi.org/10.1007/s00044-012-0373-7
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DOI: https://doi.org/10.1007/s00044-012-0373-7