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Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives

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Abstract

We report here the synthesis of a novel series of tetrazolo[1,5-a]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier–Haack reaction, the Claisen–Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity against a panel of three cell lines such as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1). Most of the synthesized compounds possess potent anticancer activity.

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ACKNOWLEDGMENTS

The authors are thankful to The Head, Department of Chemistry, Osmania University, Hyderabad for providing Laboratory facilities and one of the authors M. Nagraj thankful to UGC, New Delhi, India for financial support. We also thankful to The Director, CFRD, Osmania University, Hyderabad for providing spectral analysis facilities.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, 500007, Hyderabad, India

    R. Nagaraju, K. Gopichand, N. N. Rao, A. M. Ganai, E. Kishan & P. Venkateswar Rao

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  1. R. Nagaraju
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  2. K. Gopichand
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  3. N. N. Rao
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  4. A. M. Ganai
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  5. E. Kishan
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  6. P. Venkateswar Rao
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Correspondence to P. Venkateswar Rao.

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Nagaraju, R., Gopichand, K., Rao, N.N. et al. Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives. Russ J Gen Chem 90, 314–318 (2020). https://doi.org/10.1134/S1070363220020255

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