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Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents

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Abstract

A series of quinoline-based heterocycles prepared and bioevaluated for their possible antimicrobial activity against a panel of gram-positive bacteria [Staphylococcus aureus (ATCC-9144) and Bacillus subtilis (ATCC-6633)] and gram-negative bacteria [Pseudomonas aeruginosa (ATCC-25615), and Escherichia coli (MTCC-739)], and fungal strains [Candida albicans (ATCC-24433), Aspergillus niger (MTCC-872), and Aspergillus fumigatus (MTCC-343)] by the known methods. All the prepared quinoline derivatives have shown significant antimicrobial activities. Few compounds, viz. 4b, 4c and 4a, 4c proved to be active at low concentrations against Sa and Ca, respectively, while compounds 4a, 6d, and 6b showed milder inhibitory effects against other microbes. The structures of newly synthesized compounds were characterized by elemental analysis, Infrared (IR), 1HNMR, 13C-NMR and Mass-spectroscopy.

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Acknowledgments

The authors are thankful to the Head, Department of Chemistry, University of Lucknow, Lucknow for providing necessary Laboratory facilities and to the Director, Central Drug Research Institute (CDRI), Lucknow, India for providing spectral, elemental, and biological activity data.

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Authors and Affiliations

  1. Department of Chemistry, Lucknow University, University Road, Lucknow, 226 007, India

    Abha Bishnoi, Anil Kumar Tiwari, Suruchi Singh & Arun Sethi

  2. Division of Fermentation Technology, Central Drug Research Institute, Lucknow, 226001, India

    Chandrakant Mani Tripathi & Bikram Banerjee

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  1. Abha Bishnoi
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  2. Anil Kumar Tiwari
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  3. Suruchi Singh
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  4. Arun Sethi
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  5. Chandrakant Mani Tripathi
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  6. Bikram Banerjee
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Correspondence to Abha Bishnoi.

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Bishnoi, A., Tiwari, A.K., Singh, S. et al. Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents. Med Chem Res 22, 3527–3535 (2013). https://doi.org/10.1007/s00044-012-0333-2

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  • DOI: https://doi.org/10.1007/s00044-012-0333-2

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