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Synthesis of (substituted benzamidostyryl) lH-benzimidazoles and their screening for anti-inflammatory activity

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Abstract

A series of substituted (benzamidostyryl) benzimidazole (3a–r) were synthesized and evaluated for their possible anti-inflammatory and ulcerogenicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in carrageenan-induced hind paw edema method test and compounds 3b, 3k had shown high potency after 3 and 4 h time intervals (P < 0.001) almost equipotent to the standard drug indomethacin and showed less severity index than it.

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Acknowledgments

Authors are thankful to Hamdard University, New Delhi for generation of FT-IR and elemental analysis data. The authors are really grateful to CDRI, Lucknow for the generation of FABMS and to IIT, New Delhi and Hamdard University, New Delhi for providing the 1H-NMR spectra.

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  1. Medicinal Chemistry Division, F/o Pharmacy, Jamia Hamdard, New Delhi, India

    Darpan Kaushik, Suroor Ahmed Khan & Gita Chawla

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  1. Darpan Kaushik
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  2. Suroor Ahmed Khan
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  3. Gita Chawla
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Correspondence to Darpan Kaushik.

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Kaushik, D., Khan, S.A. & Chawla, G. Synthesis of (substituted benzamidostyryl) lH-benzimidazoles and their screening for anti-inflammatory activity. Med Chem Res 21, 459–467 (2012). https://doi.org/10.1007/s00044-011-9552-1

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  • DOI: https://doi.org/10.1007/s00044-011-9552-1

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