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Anti-inflammatory activities of some newly synthesized pyridinyl- and indazolyl benzamide derivatives

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Abstract

A series of substituted (pyridin-4-yl)phenyl-2-methoxybenzamide and their derivatives were prepared and screened for their anti-inflammatory activities. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly synthesized compounds exhibited better pharmacological and biological responses than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Cairo University Egypt, Cairo, Egypt

    Azza A. Hussain & Ahmed F. A. Shalaby

  2. Research Unit, Saco Pharm. Co., 6th October City, 11632, Egypt

    Mohamed M. Abdulla

  3. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Abd El-Galil E. Amr & Mohamed A. Al-Omar

  4. Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt

    Abd El-Galil E. Amr

Authors
  1. Azza A. Hussain
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  2. Mohamed M. Abdulla
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  3. Abd El-Galil E. Amr
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  4. Mohamed A. Al-Omar
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  5. Ahmed F. A. Shalaby
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Correspondence to Azza A. Hussain.

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Hussain, A.A., Abdulla, M.M., Amr, A.EG.E. et al. Anti-inflammatory activities of some newly synthesized pyridinyl- and indazolyl benzamide derivatives. Russ J Bioorg Chem 41, 87–96 (2015). https://doi.org/10.1134/S106816201405015X

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  • DOI: https://doi.org/10.1134/S106816201405015X

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