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In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide

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Abstract

A variety of N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide, 7a–r were synthesized by using 2-aminopyridine, isonicotic acid hydrazide and cyanuric chloride, and the structures of these compounds were confirmed by IR and NMR (1H and 13C) spectral analyses. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system.

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Acknowledgements

Antimycobacterial data were provided by the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF, USA) as part of a research and development contract with the US National Institute of Allergy and Infectious Diseases. JPR is thankful to Charutar Vidyamandal and SICART, Vallabh Vidyanagar, Gujarat for providing the necessary research and spectral facilities, respectively.

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  1. Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Gujarat, 388121, India

    Jignesh Priyakant Raval, Nilesh Hasmukhbhai Patel, Hemul Vinubhai Patel & Pradip Shantibhai Patel

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  1. Jignesh Priyakant Raval
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  2. Nilesh Hasmukhbhai Patel
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  3. Hemul Vinubhai Patel
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  4. Pradip Shantibhai Patel
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Correspondence to Jignesh Priyakant Raval.

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Raval, J.P., Patel, N.H., Patel, H.V. et al. In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide. Med Chem Res 20, 274–279 (2011). https://doi.org/10.1007/s00044-010-9324-3

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  • DOI: https://doi.org/10.1007/s00044-010-9324-3

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