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Synthesis and biological activity of new cycloalkylthiophene-Schiff bases and their Cr(III) and Zn(II) complexes

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Abstract

A series of some novel Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-5,6-dihydro-4H-cyclopenta[b]thiopehene-3-carboxylate, Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, Ethyl 2-((1-hydroxynaphtalen-2-yl)methyleneamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate and their Cr(III) and Zn(II) complexes have been synthesized. All of these substances have been examined for antibacterial activity against pathogenic strains Listeria monocytogenes 4b (ATCC-19115), Staphylococcus aureus (ATCC25923), Proteus OX2 Wrah (ETS.40-A-4), Escherichia coli (ATCC-1280), Salmonella typhi H (NCTC-901.8394), Pseudomonas putida sp., Brucella abortus (A.99, UK-1995) RSKK-03026. Sh. boydii type 11 (Pasteur51.6), Sh. boydii type 16 (cHe 67.11), Sh. boydii type 6 (RSKK-96043), and antifungal activity against Candida albicans (Y-1200-NIH, Tokyo). Some of the compounds exhibited activity comparable to ampicillin ofloxacin, nystatin, kanamycin, sulphamethoxazol, amoxycillin, and chloroamphenicol. Most of the studied compounds were found effective against bacteria studied and yeast.

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Acknowlegments

The authors thank the Gazi Üniversity Research Fund (Project number: 05/2009-20) for financial support and Elif Loğoğlu, Nazlıgül Tolu, and İsmail Kutlu for antibacterial studies.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Arts, Gazi University, 06500, Teknikokullar, Ankara, Turkey

    Aliye Altundas & Nurşen Sarı

  2. Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey

    Naki Colak

  3. Refik Saydam Hygiene Center, 06100, Ankara, Turkey

    Hatice Ögütcü

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  1. Aliye Altundas
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  2. Nurşen Sarı
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  3. Naki Colak
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  4. Hatice Ögütcü
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Correspondence to Nurşen Sarı.

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Altundas, A., Sarı, N., Colak, N. et al. Synthesis and biological activity of new cycloalkylthiophene-Schiff bases and their Cr(III) and Zn(II) complexes. Med Chem Res 19, 576–588 (2010). https://doi.org/10.1007/s00044-009-9214-8

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  • DOI: https://doi.org/10.1007/s00044-009-9214-8

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