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Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

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Abstract

Growth factors and cytokines are key regulators of the wound-healing process. Epidermal growth factor (EGF) plays a vital role during the process of wound healing. There are limited numbers of studies related to EGF implantation effects on oxidative stress in oral wound healing. The objective of this study was to investigate the effect of EGF on myeloperoxidase (MPO) activity and nonenzymatic antioxidant levels of oral wound tissue on different days. In this study, New Zealand male albino rabbits were used. After submucosal incisions, the rabbits were divided into two equal groups: untreated wounds, and EGF-implanted wounds. The levels of glutathione (GSH), ascorbic acid (AA), and MPO activity were measured spectrophotometrically. As a result, MPO activity of oral wound tissue strips was increased by exogenous EGF treatment compared with controls. In addition, GSH and AA levels of oral wound tissue strips were not changed during oral wound-healing phases for both controls and experimental groups.

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Acknowledgement

This investigation was supported by the Gazi University Research Foundation. Ankara, Turkey (BAP 05/2003-24).

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Authors and Affiliations

  1. Department of Biology and Physiology, Faculty of Science and Art, Gazi University, 06500, Beşevler, Ankara, Turkey

    Emine Gülçeri Güleç Peker & Şule Coşkun

  2. Department of Statistics, Faculty of Science and Art, Gazi University, 06500, Beşevler, Ankara, Turkey

    Meral Ebegil

  3. Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey

    Füsun Acartürk

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  1. Emine Gülçeri Güleç Peker
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  2. Şule Coşkun
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  3. Meral Ebegil
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Correspondence to Emine Gülçeri Güleç Peker.

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Güleç Peker, E.G., Coşkun, Ş., Ebegil, M. et al. Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue. Med Chem Res 19, 533–540 (2010). https://doi.org/10.1007/s00044-009-9210-z

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  • DOI: https://doi.org/10.1007/s00044-009-9210-z

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