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Effects of Epidermal Growth Factor on Lipid Peroxidation and Nitric Oxide Levels in Oral Mucosal Ulcer Healing: A Time-Course Study

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Abstract

Purpose

Epidermal growth factor (EGF) has been used as a vulnerary agent. Epidermal growth factor accelerates wound healing. Nitric oxide (NO) is considered to be an important factor which is involved in wound healing. The objective of this study was to examine the effects of interactions between exogenous EGF and NOx which may have either similar or quite opposed properties in the process of oral wound repair on different days. In addition, lipid peroxidation was found to be an indicator of free radical damage.

Methods

Five-month-old New Zealand albino male rabbits were used for this study. A surgical incision was made in the right mandibula diestema region of the rabbits, which were then divided into controls and EGF implanted groups. All parameters were analyzed by spectrophotometry.

Results

In the EGF-implanted groups, both the NOx and lipid peroxidation indicator levels significantly decreased in comparison to those of the control groups on the first day after wounding. However, on the 3rd and 5th days after wounding, the NOx levels of the tissue strips also decreased in both modalities, but there was no significant alteration between the 3rd and 5th day after wounding.

Conclusion

It was concluded that EGF affects oral wound healing by downregulating both the lipid peroxidation and NOx levels, and it may thus be considered to be an oxygen radical scavenger.

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Authors and Affiliations

  1. Department of Biology, Arts and Science Faculty, Gazi University, 06500, Teknikokullar, Ankara, Turkey

    Şule Coşkun, Emine Gülçeri Güleç & Barbaros Balabanli

  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey

    Füsun Acartürk

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  1. Şule Coşkun
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  2. Emine Gülçeri Güleç
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  3. Barbaros Balabanli
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  4. Füsun Acartürk
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Coşkun, Ş., Güleç, E., Balabanli, B. et al. Effects of Epidermal Growth Factor on Lipid Peroxidation and Nitric Oxide Levels in Oral Mucosal Ulcer Healing: A Time-Course Study. Surg Today 37, 570–574 (2007). https://doi.org/10.1007/s00595-006-3455-7

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  • DOI: https://doi.org/10.1007/s00595-006-3455-7

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