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Synthesis of bioactive spiro-2-[3′-(2′-phenyl)-3H-indolyl]-1-aryl-3-phenylaziridines and SAR studies on their antimicrobial behavior

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Abstract

The present communication deals with synthesis of a new series of spiro-2-[3′-(2′-phenyl)-3H-indolyl]-1-aryl-3-phenylaziridines. Infrared (IR), 1H nuclear magnetic resonance (NMR), mass spectral, and elemental analysis data corroborated the structure of all synthesized compounds. Synthesized compounds were screened for antimicrobial activity against a representative panel of Gram-positive and Gram-negative bacteria. All newly synthesized compounds showed remarkable antimicrobial behavior. Structure–activity relationship (SAR) investigations were applied to investigate the correlation between the molecular refractive index (MR) parameter of the compounds and their biological activity profile. All compounds were subjected to acute toxicity studies to determine 50% lethal dose (LD50) values.

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Acknowledgements

The authors would like to thank the Central Drug Research Institute, Lucknow, India for providing spectroanalytical facilities and to the Council of Scientific and Industrial Research (CSIR), New Delhi for providing financial assistance.

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Authors and Affiliations

  1. School of Chemical Sciences, Devi Ahilya University, Indore, MP, 452 001, India

    Pratibha Sharma, Ashok Kumar, Vinita Sahu, Siya Upadhyay & Jitendra Singh

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  1. Pratibha Sharma
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  2. Ashok Kumar
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  3. Vinita Sahu
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  4. Siya Upadhyay
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  5. Jitendra Singh
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Correspondence to Pratibha Sharma.

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Sharma, P., Kumar, A., Sahu, V. et al. Synthesis of bioactive spiro-2-[3′-(2′-phenyl)-3H-indolyl]-1-aryl-3-phenylaziridines and SAR studies on their antimicrobial behavior. Med Chem Res 18, 383–395 (2009). https://doi.org/10.1007/s00044-008-9135-y

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