Abstract
The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth. Here, we will briefly introduce the Hippo tumor suppressor pathway before focusing on one of its members and the unexpected twists that followed our quest of its functions in its multifarious actions beside the Hippo pathway: the STK38 kinase. In this review, we will precisely discuss the newly identified role of STK38 on regulating the nuclear export machinery by phosphorylating and activating, the major nuclear export receptor XPO1. Finally, we will phrase STK38′s role on regulating the subcellular distribution of crucial cellular regulators such as Beclin1 and YAP1 with its implication in cancer.
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Acknowledgements
We thank our collaborators who participated in this work with inventive ideas, in particular: A. Hergovitch from UC; MK Singh from Paris; MC. Parrini, and B. Meunier from Institut Curie Paris; V. Aushev from Mount Sinai New-York; P. Codogno and C. Guerera and her collaborators from the mass spectrometry platform of INEM Paris; N. Carpi and M. Piel from IPGG Paris; and D. Daelemans and M. Jacquemyn from KU Leuven. We also apologize to colleagues whose work was not cited because of the space limitations of this review.
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Martin, A.P., Aushev, V.N., Zalcman, G. et al. The STK38–XPO1 axis, a new actor in physiology and cancer. Cell. Mol. Life Sci. 78, 1943–1955 (2021). https://doi.org/10.1007/s00018-020-03690-w
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DOI: https://doi.org/10.1007/s00018-020-03690-w