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Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation

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Abstract

Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.

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Funding

Support obtained from the Federal University of Rio Grande do Norte, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Grants 308775/2015-5 and 408145/2016-1 to SR; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (STIC AmSud 062/2015) to SR; Fundação de Amparo à Pesquisa do Rio Grande do Norte Grant Pronem 003/2011 to SR; Fundação de Amparo à Pesquisa do Estado de São Paulo Grant #2013/07699-0 Center for Neuromathematics to SR, Pew Latin American Fellows Program to SR; CAPES/COFECUB Grant 783/13 to CMQ; CAPES PhD scholarship to DGAF.

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  1. Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, 59056-450, Brazil

    Daniel G. Almeida-Filho, Claudio M. Queiroz & Sidarta Ribeiro

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Almeida-Filho, D.G., Queiroz, C.M. & Ribeiro, S. Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation. Cell. Mol. Life Sci. 75, 3715–3740 (2018). https://doi.org/10.1007/s00018-018-2886-9

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  • DOI: https://doi.org/10.1007/s00018-018-2886-9

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