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Melatonin and mitochondrial function during ischemia/reperfusion injury

  • Multi-author review
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An Author Correction to this article was published on 24 April 2018

This article has been updated

Abstract

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin’s protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.

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Change history

  • 24 April 2018

    In the original publication, affiliations were incorrectly published for the authors.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81500263) and China Postdoctoral Science Foundation (2016T90973 and 2015M572681).

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  1. Zhiqiang Ma and Zhenlong Xin contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, UT Health San Antonio, 229 Taibai North Road, Xi’an, 710069, China

    Zhiqiang Ma, Russel J. Reiter & Yang Yang

  2. Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xi’an, 710038, China

    Zhiqiang Ma, Xiaolong Yan & Xiaofei Li

  3. Department of Biomedical Engineering, Fourth Military Medical University, 169 Changle West Road, Xi’an, 710032, China

    Zhenlong Xin

  4. Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China

    Wencheng Di

  5. Department of Cellular and Structural Biology, UT Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA

    Yang Yang

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  1. Zhiqiang Ma
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Ma, Z., Xin, Z., Di, W. et al. Melatonin and mitochondrial function during ischemia/reperfusion injury. Cell. Mol. Life Sci. 74, 3989–3998 (2017). https://doi.org/10.1007/s00018-017-2618-6

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