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Endothelial cell apoptosis in angiogenesis and vessel regression

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Abstract

Blood vessel regression is an essential process for ensuring blood vessel networks function at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they change over time. Angiogenesis is the major mechanism by which new blood vessels are produced, but the vessel growth associated with angiogenesis must be complemented by remodeling and maturation events including the removal of redundant vessel segments and cells to fashion the newly forming vasculature into an efficient, hierarchical network. This review will summarize recent findings on the role that endothelial cell apoptosis plays in vascular remodeling during angiogenesis and in vessel regression more generally.

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Abbreviations

EC:

Endothelial cell

OIR:

Oxygen-induced retinopathy

DISC:

Death-inducing signaling complex

TUNEL:

Terminal deoxynucleotidyl transferase dUTP nick end labeling

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Acknowledgements

The work of the authors is supported by the National Health and Medical Research Council, Australia (Project Grant: 1125536), Australian Government Research Training Program Scholarships (to ECW and ZLG), and the L.E.W Carty Charitable Fund. The work is made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.

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  1. Emma C. Watson

    Present address: Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, 48149, Münster, Germany

Authors and Affiliations

  1. Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia

    Emma C. Watson, Zoe L. Grant & Leigh Coultas

  2. Department of Medical Biology, University of Melbourne, 1G Royal Parade, Parkville, VIC, 3052, Australia

    Emma C. Watson, Zoe L. Grant & Leigh Coultas

  3. Faculty of Medicine, University of Münster, 48149, Münster, Germany

    Emma C. Watson

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Watson, E.C., Grant, Z.L. & Coultas, L. Endothelial cell apoptosis in angiogenesis and vessel regression. Cell. Mol. Life Sci. 74, 4387–4403 (2017). https://doi.org/10.1007/s00018-017-2577-y

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