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Tumor suppressor role of protein 4.1B/DAL-1

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Abstract

Protein 4.1B/DAL-1 is a membrane skeletal protein that belongs to the protein 4.1 family. Protein 4.1B/DAL-1 is localized to sites of cell–cell contact and functions as an adapter protein, linking the plasma membrane to the cytoskeleton or associated cytoplasmic signaling effectors and facilitating their activities in various pathways. Protein 4.1B/DAL-1 is involved in various cytoskeleton-associated processes, such as cell motility and adhesion. Moreover, protein 4.1B/DAL-1 also plays a regulatory role in cell growth, differentiation, and the establishment of epithelial-like cell structures. Protein 4.1B/DAL-1 is normally expressed in multiple human tissues, but loss of its expression or prominent down-regulation of its expression is frequently observed in corresponding tumor tissues and tumor cell lines, suggesting that protein 4.1B/DAL-1 is involved in the molecular pathogenesis of these tumors and acts as a potential tumor suppressor. This review will focus on the structure of protein 4.1B/DAL-1, 4.1B/DAL-1-interacting molecules, 4.1B/DAL-1 inactivation and tumor progression, and anti-tumor activity of the 4.1B/DAL-1.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81270576, 81301774, 81301997), New Century Excellent Talents in University (NCET-11-0518), Doctoral Fund of Ministry of Education of China (No. 20120162110054), the fundamental research funds for the central universities (No. 2011JQ015).

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Molecular Biology Research Center, School of Life Sciences, Central South University, 110 Xiangya Road, Changsha, 410078, China

    Zi Wang, Ji Zhang, Min Zhu, Mridul Roy & Jing Liu

  2. Department of Hematology, The First Affiliated Hospital, University of South China, Hengyang, 421001, China

    Ji Zhang

  3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, 410082, China

    Mao Ye

  4. Department of Histology and Embryology, Xiangya School Medicine, Central South University, Changsha, 410083, China

    Bin Zhang

  5. State Key Laboratory of Medical Genetics, Central South University, 110 Xiangya Road, Changsha, 410078, China

    Jing Liu

  6. Laboratory of Membrane Biology, New York Blood Center, 310 E 67th Street, New York, 10065, USA

    Xiuli An

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  1. Zi Wang
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  2. Ji Zhang
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  3. Mao Ye
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  4. Min Zhu
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  5. Bin Zhang
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  6. Mridul Roy
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  7. Jing Liu
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  8. Xiuli An
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Corresponding authors

Correspondence to Jing Liu or Xiuli An.

Additional information

Z. Wang, J. Zhang, and M. Ye contributed equally to this work.

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Wang, Z., Zhang, J., Ye, M. et al. Tumor suppressor role of protein 4.1B/DAL-1. Cell. Mol. Life Sci. 71, 4815–4830 (2014). https://doi.org/10.1007/s00018-014-1707-z

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  • DOI: https://doi.org/10.1007/s00018-014-1707-z

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