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Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia

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Abstract

Cancer is often caused by deregulation of normal developmental processes. Here, we review recent research on the aberrant activation of two hematopoietic cytokine receptors in acute lymphoid leukemias. Somatic events in the genes for thymic stromal lymphopoietin and Interleukin 7 receptors as well as in their downstream JAK kinases result in constitutive ligand-independent activation of survival and proliferation in B and T lymphoid precursors. Drugs targeting these receptors or the signaling pathways might provide effective therapies of these leukemias.

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Acknowledgments

This article was made possible through research support by the Israel Science Foundation Legacy and i-CORE programs, by the Waxman Cancer Foundation, the Swiss Bridge Foundation, the William Lawrence & Blanche Hughes Foundation, Children With Cancer UK, the Clinical Genetic Foundation and the Israel Cancer Research Foundation. It is part of the requirements for a PhD at Tel Aviv University of Noa Tal, Chen Shochat and Ifat Geron. We are indebt to present and past members of our laboratory, especially to Ithamar Ganmore and Libi Hertzberg, and to our many collaborators in Israel and abroad in studying these leukemias.

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Authors and Affiliations

  1. Cancer Research Center, Sheba Medical Center, Edmond and Lily Safra Children’s Hospital, Tel Hashomer, 52621, Ramat Gan, Israel

    Noa Tal, Ifat Geron & Shai Izraeli

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Noa Tal, Chen Shochat, Ifat Geron & Shai Izraeli

  3. Migal Galilee Technology Center, Kiryat Shmona, Israel

    Chen Shochat & Dani Bercovich

  4. Tel Hai College, 12210, Upper Galilee, Israel

    Chen Shochat & Dani Bercovich

  5. Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California San Diego, La Jolla, California, USA

    Ifat Geron

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  1. Noa Tal
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  2. Chen Shochat
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  3. Ifat Geron
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  4. Dani Bercovich
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  5. Shai Izraeli
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Correspondence to Shai Izraeli.

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Tal, N., Shochat, C., Geron, I. et al. Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia. Cell. Mol. Life Sci. 71, 365–378 (2014). https://doi.org/10.1007/s00018-013-1337-x

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  • DOI: https://doi.org/10.1007/s00018-013-1337-x

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