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Functions of the poly(ADP-ribose) polymerase superfamily in plants

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Abstract

Poly(ADP-ribosyl)ation is the covalent attachment of ADP-ribose subunits from NAD+ to target proteins and was first described in plants in the 1970s. This post-translational modification is mediated by poly(ADP-ribose) polymerases (PARPs) and removed by poly(ADP-ribose) glycohydrolases (PARGs). PARPs have important functions in many biological processes including DNA repair, epigenetic regulation and transcription. However, these roles are not always associated with enzymatic activity. The PARP superfamily has been well studied in animals, but remains under-investigated in plants. Although plants lack the variety of PARP superfamily members found in mammals, they do encode three different types of PARP superfamily proteins, including a group of PARP-like proteins, the SRO family, that are plant specific. In plants, members of the PARP family and/or poly(ADP-ribosyl)ation have been linked to DNA repair, mitosis, innate immunity and stress responses. In addition, members of the SRO family have been shown to be necessary for normal sporophytic development. In this review, we summarize the current state of plant research into poly(ADP-ribosyl)ation and the PARP superfamily in plants.

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Acknowledgments

We thank Dr. Patrice Hamel, Dr. David Mackey and Dr. Iris Meier (Ohio State University), members of the Lamb laboratory and an anonymous reviewer for helpful advice on the manuscript. We apologize to colleagues whose work we could not include due to space limitations.

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Authors and Affiliations

  1. Department of Molecular Genetics, The Ohio State University, 500 Aronoff Laboratory, 318 W. 12th Ave, Columbus, OH, 43210, USA

    Rebecca S. Lamb & Matteo Citarelli

  2. School of Biotechnology, Gautam Buddha University, Greater Noida, U.P., 201308, India

    Sachin Teotia

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  1. Rebecca S. Lamb
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  2. Matteo Citarelli
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Correspondence to Rebecca S. Lamb.

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A recent review on this subject covering similar but not identical data was published during review of this manuscript [24].

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Lamb, R.S., Citarelli, M. & Teotia, S. Functions of the poly(ADP-ribose) polymerase superfamily in plants. Cell. Mol. Life Sci. 69, 175–189 (2012). https://doi.org/10.1007/s00018-011-0793-4

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