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Role of host-defence peptides in eye diseases

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Abstract

The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarised. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed.

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Abbreviations

HDP:

Host-defence peptide

hBD:

Human β-defensin

mBD:

Mouse β-defensin

HNP:

Human neutrophil peptide

LL-37:

Human cathelicidin

CRAMP:

Cathelin-related antimicrobial peptide

LPS:

Lipopolysaccharide

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Acknowledgments

The authors thank Ms. Kimberly Thompson of the University of Houston, College of Optometry Audio Visual Services for drawing Fig. 1. The authors’ research on HDPs in the eye is supported by grants from the National Eye Institute (EY13175, EY7551) and collaborative grants with Dr. C. Cai awarded by the National Science Foundation (DMR-0706627) and National Eye Institute (EY18303).

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  1. College of Optometry, University of Houston, 4901 Calhoun Road, 505 J Davis Armistead Bldg, Houston, TX, 77204-2020, USA

    Satya S. Kolar & Alison M. McDermott

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  1. Satya S. Kolar
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Correspondence to Alison M. McDermott.

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Kolar, S.S., McDermott, A.M. Role of host-defence peptides in eye diseases. Cell. Mol. Life Sci. 68, 2201–2213 (2011). https://doi.org/10.1007/s00018-011-0713-7

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