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Posttranslational modification of mammalian AP endonuclease (APE1)

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Abstract

A key issue in studying mammalian DNA base excision repair is how its component proteins respond to a plethora of cell-signaling mediators invoked by DNA damage and stress-inducing agents such as reactive oxygen species, and how the actions of individual BER proteins are attributed to cell survival or apoptotic/necrotic death. This article reviews the past and recent progress on posttranslational modification (PTM) of mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1).

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Abbreviations

AP:

Apurinic/apyrimidinic

APE:

AP endonuclease

APE1:

AP endonuclease 1

BER:

Base excision repair

CKII:

Casein kinase II

FEN1:

Flap endonuclease 1

HAT:

Histone acetyltransferase

HDAC:

Histone deacetylase

MDM2:

Mouse double minute 2

NAM:

Nicotinamide

nCaRE:

Negative calcium response element

NPM1:

Nucleophosmin

PARP1:

Poly(ADP-ribose) polymerase 1

PKC:

Protein kinase C

Pol B:

DNA polymerase beta

Ref-1:

Redox factor 1

ROS:

Reactive oxygen species

SSB:

Single-strand break

PTM:

Posttranslational modification

SNP:

Single nucleotide polymorphism

TF:

Transcription factor

TSA:

Trichostatin A

XRCC1:

X-ray repair cross complementation group 1

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Acknowledgments

While we were in the final process of revision, Huang et al. newly reported that APE1 was phosphorylated at Thr 233, resulting in a decrease of the APE activity, particularly in brain tissues from patients with Parkinson’s and Alzheimer’s diseases (Nat Cell Biol 12:563–571, 2010). A significant question in relation to this review is if and how T233 phosphorylation affects the intracellular levels of acetylated and ubiquitinated APE1. This work was supported by NIH CA98664 (TI).

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  1. Department of Otorhinolaryngology and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA

    Carlos S. Busso, Michael W. Lake & Tadahide Izumi

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  1. Carlos S. Busso
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Correspondence to Tadahide Izumi.

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Busso, C.S., Lake, M.W. & Izumi, T. Posttranslational modification of mammalian AP endonuclease (APE1). Cell. Mol. Life Sci. 67, 3609–3620 (2010). https://doi.org/10.1007/s00018-010-0487-3

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