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Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair

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Abstract

Nucleotide excision repair (NER) is one of the major DNA repair pathways aimed at maintaining genome stability. Correction of DNA damage by the NER system is a multistage process that proceeds with the formation of multiple DNA-protein and protein-protein intermediate complexes and requires precise coordination and regulation. NER proteins undergo post-translational modifications, such as ubiquitination, sumoylation, phosphorylation, acetylation, and poly(ADP-ribosyl)ation. These modifications affect the interaction of NER factors with DNA and other proteins and thus regulate either their recruitment into the complexes or dissociation from these complexes at certain stages of DNA repair, as well as modulate the functional activity of NER proteins and control the process of DNA repair in general. Here, we review the data on the post-translational modifications of NER factors and their effects on DNA repair. Protein poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 and its impact on NER are discussed in detail, since such analysis has not been done before.

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Abbreviations

BPDE:

benz[a]pyrene diol epoxide

CPD:

cyclobutane pyrimidine dimer

GG-NER:

global genome nucleotide excision repair

NER:

nucleotide excision repair

PAR:

poly(ADP-ribose)

PARP:

poly(ADP-ribose) polymerase

RNAP:

RNA polymerase

RPA:

replication protein A

SUMO:

small ubiquitin-like modifier

TC-NER:

transcription-coupled NER

TFIIH:

transcription factor IIH

XP:

xeroderma pigmentosum

XPC and XPA:

xeroderma pigmentosum factors C and A, respectively

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Acknowledgements. The authors are grateful to Yu. S. Krasikova for help in the manuscript preparation.

Funding

Funding. The work was supported by the Russian Foundation for Basic Research (projects nos. 18-04-00596 and 19-04-00481) and the Program of Basic Scientific Research of the State Academies of Sciences for 2013–2020 (nos. AAAA-A17-117020210022-4 for O.I.L.).

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

    N. I. Rechkunova, E. A. Maltseva & O. I. Lavrik

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    N. I. Rechkunova & O. I. Lavrik

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  1. N. I. Rechkunova
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  2. E. A. Maltseva
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Correspondence to N. I. Rechkunova.

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Russian Text © The Author(s), 2019, published in Biokhimiya, 2019, Vol. 84, No. 9, pp. 1244–1258.

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Rechkunova, N.I., Maltseva, E.A. & Lavrik, O.I. Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair. Biochemistry Moscow 84, 1008–1020 (2019). https://doi.org/10.1134/S0006297919090037

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