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The comments by Nowak-Slieinska et al. are an extension of our review article. We agree with the authors that vascular normalization is an important event that decides the outcome of anti-angiogenesis therapies. As reported by Jain RK et al. [1], antiangiogenic agents can normalize the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery. Therefore, induction of vascular normalization caused by anti-angiogenic agents provides a novel means of effective delivery of chemotherapeutic drugs. Our report was based on the effective use of anti-angiogenesis therapy to improve therapeutic efficacy of PDT. The authors agree that the use of anti-angiogenesis agents before PDT to induce vascular normalization and increase the homogenous effect of oxygen-dependent PDT is an interesting hypothesis that is worth pursuing.
Reference
Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706):58–62 Review
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Bhuvaneswari, R., Gan, Y.Y., Soo, K.C. et al. Author’s reply to comment on “The effect of photodynamic therapy on tumor angiogenesis. Cellular and Molecular Life Sciences, 66, 2275–2283”. Cell. Mol. Life Sci. 67, 1561 (2010). https://doi.org/10.1007/s00018-010-0295-9
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DOI: https://doi.org/10.1007/s00018-010-0295-9