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While there is evidence that iron may play a pathogenic role in both type 2 diabetes mellitus and Alzheimer’s disease, this can be extended to other biometals. For example, zinc transport has been suggested as a therapeutic target in type 2 diabetes mellitus [1]. Similarly, a role for zinc transporters has been proposed for Alzheimer’s and Pick’s disease [2]. Copper is a third biometals which has been implicated in both diseases [3, 4].
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Götz, J., Ittner, L.M. & Lim, YA. Response to the comment ‘Iron, type 2 diabetes mellitus, and Alzheimer’s disease’ to our Visions and Reflections article ‘Common features between diabetes mellitus and Alzheimer’s disease’. Cell. Mol. Life Sci. 66, 2945 (2009). https://doi.org/10.1007/s00018-009-0073-8
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DOI: https://doi.org/10.1007/s00018-009-0073-8