Cheng T, Chimeh C, Lu Z, et al. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Bio Biophs. 2007;460(2):213–7.
Google Scholar
Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 2008;88(2):582–6.
Google Scholar
Holick M, Schnoes H, Deluca H, Suda T, Cousins R. Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochem. 1971;10(14):2799–804.
CAS
Google Scholar
Adams J, Hewison M. Extrarenal expression of the 25-hydroxyvitamin d-1-hydroxylase. Arch Biochem Biophys. 2012;523(1):95–102.
PubMed
CAS
PubMed Central
Google Scholar
Haddad J, Vitamin D. Binding protein (Gc-globulin): multiple tasks. J Steroid Biochem Mol Biol. 1996;53(1–6):579–82.
Google Scholar
Sutton A, MacDonald P. Vitamin D: more than a “bone-a-fide” hormone. Mol Endocrinol. 2003;17(5):777–91.
PubMed
CAS
Google Scholar
White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76(9):3837–43.
PubMed
CAS
PubMed Central
Google Scholar
Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009;30(3):131–41.
PubMed
CAS
PubMed Central
Google Scholar
Wang T, Nestel F, Bourdeau V, et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004;173(5):2909–12.
PubMed
CAS
Google Scholar
Hayes C, Nashold F, Spach K, Pedersen L. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 2003;49(2):277–300.
CAS
Google Scholar
Topilski I, Flaishon L, Naveh Y, Harmelin A, Levo Y, Shachar I. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing. Eur J Immunol. 2004;34(4):1068–76.
PubMed
CAS
Google Scholar
Maxmen A. Nutrition advice: the vitamin D-lemma. Nature. 2011;475(7354):23–5.
PubMed
CAS
Google Scholar
Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167(16):1730–7.
PubMed
CAS
Google Scholar
For health professionals: position statement on supplementation, blood levels and sun exposure Vitamin D Council. Vitamin D Council. Jan 12, 2010. Available at http://www.vitamindcouncil.org/further-topics/for-health-professionals-position-statement-on-supplementation-blood-levels-and-sun-exposure/. Accessed 28 Apr 2013.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012;97(4):1153–8.
PubMed
CAS
Google Scholar
Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Dietary reference intakes for calcium and vitamin D. Washington: National Academy of Sciences; 2010. 0-309-16394-3.
Beers M. Vitamin D Deficiency and Dependency. Merck (Document). Oct 15, 2006. Available at http://web.archive.org/web/20061015162329/www.merck.com/mrkshared/mmanual/section1/chapter3/3d.jsp. Accessed 21 Apr 2013.
Topiwala S. 25-hydroxy vitamin D test. MedlinePlus. Oct 7, 2012. Available at http://www.nlm.nih.gov/medlineplus/ency/article/003569.htm. Accessed 21 Apr 2013.
Vitamin D, 25-Hydroxy, LC/MS/MS. Quest diagnostics. 2013. Available at http://www.questdiagnostics.com/home/physicians/testing-services/by-test-name/vitamind.html. Accessed 28 Apr 2013.
Snellman G, Melhus H, Gedeborg R, et al. Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. PLoS One. 2009;4(11):e7747.
PubMed
PubMed Central
Google Scholar
Bogh MK, Schmedes AV, Philipsen PA, Thieden E, Wulf HC. Vitamin D production depends on ultraviolet-B dose but not on dose rate: a randomized controlled trial. Exp Dermatol. 2011;20(1):14–8.
PubMed
CAS
Google Scholar
Bogh MK, Schmedes AV, Philipsen PA, Theiden E, Wulf HC. Vitamin D production after UVB exposure depends on baseline vitamin D and total cholesterol but not on skin pigmentation. J Invest Dermatol. 2010;130(2):546–53.
PubMed
CAS
Google Scholar
Matsuoka LY, Worstman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol. 1991;127(4):536–8.
PubMed
CAS
Google Scholar
Matsuoka LY, Wortsman J, Chen TC, Holick MF. Compensation for the interracial variance in the cutaneous synthesis of vitamin D. J Lab Clin Med. 1995;126(5):452–7.
PubMed
CAS
Google Scholar
Villa M, Kelsey J, Chen J, Marcus R. Skin Pigmentation does not affect vitamin D status in community-dwelling Mexican–American women. J Bone Miner Res. 1994;9(Suppl 1):S418.
Google Scholar
Matsuoka LY, Wortsman J, Dannenberg MJ, Holis BW, Lu Z, Holick MF. Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3. J Clin Endocrinol Metab. 1992;75(4):1099–103.
PubMed
CAS
Google Scholar
Dietary supplement fact sheet: vitamin D. National Institutes of Health. Jan 24, 2011. Available at http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/?print=1. Accessed 10 Mar 2013.
Matsuoka LY, Ide L, MacLaughlin JA, Holick MF. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab. 1987;64(6):1165–8.
PubMed
CAS
Google Scholar
Diehl JW, Chiu MW. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatol Ther. 2010;23(1):48–60.
PubMed
Google Scholar
Youl PH, Janda M, Kimlin M. Vitamin D and sun protection: the impact of mixed public health messages in Australia. Int J Cancer. 2009;124(8):1963–70.
PubMed
CAS
Google Scholar
Global Solar UV Index: A Practical Guide. Geneva, Switzerland: World Health Organization; 2002. ISBN 9241590076.
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536–8.
PubMed
CAS
PubMed Central
Google Scholar
Chuck A, Todd J, Diffey B. Subliminal ultraviolet-B irradiation for the prevention of vitamin D deficiency in the elderly: a feasibility study. Photodermatol Photoimmunol Photomed. 2001;17(4):168–71.
PubMed
CAS
Google Scholar
Chel VG, Ooms ME, Popp-Snijders C, et al. Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J Bone Miner Res. 1998;13(8):1238–42.
PubMed
CAS
Google Scholar
Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. Clin Endocrinol Metab. 1988;67(2):373–8.
CAS
Google Scholar
Kimlin MG, Olds WJ, Moore MR. Location and vitamin D synthesis: is the hypothesis validated by geophysical data? J Photochem Photobiol B. 2007;86(3):234–9.
PubMed
CAS
Google Scholar
Lubin D, Jensen EH, Gies HP. Global surface ultraviolet radiation climatology from TOMS and ERBE data. J Geo Res. 1998;103(D20):26061–91.
Google Scholar
Schoenmakers I, Goldberg GR, Prentice A. Abundant sunshine and vitamin D deficiency. Br J Nutr. 2008;99(6):1171–3.
PubMed
CAS
PubMed Central
Google Scholar
Al-Othman A, Al-Musharaf S, Al-Daghri NM, et al. Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents. Nutr J. 2012;11:56.
PubMed
CAS
PubMed Central
Google Scholar
Willis KS, Smith DT, Broughton KS, Larson-Meyer DE. Vitamin D status and biomarkers of inflammation in runners. Open Access J Sports Med. 2012;2012(3):35–42.
Google Scholar
Binkley N, Novotny R, Krueger D, et al. Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab. 2007;92(6):2130–5.
PubMed
CAS
Google Scholar
Blaney GP, Albert PJ, Proal AD. Vitamin D metabolites as clinical markers in autoimmune and chronic disease. Ann NY Acad Sci. 2009;1173:384–90.
PubMed
CAS
Google Scholar
Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr. 1999;53(12):920–6.
PubMed
CAS
Google Scholar
Tiosano D, Hochberg Z. Hypophosphatemia: the common denominator of all rickets. J Bone Miner Metab. 2009;27(4):392–401.
PubMed
Google Scholar
Rickets. MedlinePlus. Aug 1, 2012. Available at http://www.nlm.nih.gov/medlineplus/ency/article/000344.htm. Accessed 6 May 2013.
Lerch C, Meissner T. Interventions for the prevention of nutritional rickets in term born children. Cochrane Database Syst Rev. 2007;4:CD006164.
Pettifor JM, Ross P, Wang J, Moodley G, Couper-Smith J. Rickets in children of rural origin in South Africa: is low dietary calcium a factor? J Pediatr. 1978;92(2):320–4.
PubMed
CAS
Google Scholar
Pettifor JM. Nutritional rickets: deficiency of vitamin D, calcium, or both? Am J Clin Nutr. 2004;80(6 Suppl):1725S–9S.
PubMed
CAS
Google Scholar
Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2013;383:146–55.
PubMed
Google Scholar
Boden SD, Kaplan FS. Calcium homeostasis. Orthop Clin North Am. 1990;21(1):31–42.
PubMed
CAS
Google Scholar
Sun J. Vitamin D and mucosal immune function. Curr Opin Gastroenterol. 2010;26(6):591–5.
PubMed
CAS
PubMed Central
Google Scholar
Abreu MT, Kantorovich V, Vasiliauskas EA, et al. Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn’s disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Gut. 2004;53(8):1129–36.
PubMed
CAS
PubMed Central
Google Scholar
Brot C, Jørgensen N, Madsen OR, Jensen LB, Sørensen OH. Relationships between bone mineral density, serum vitamin D metabolites and calcium:phosphorus intake in healthy perimenopausal women. J Intern Med. 1999;245(5):509–16.
PubMed
CAS
Google Scholar
Ishizuka S, Kurihara N, Miura D, et al. Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D3 from pagetic bone marrow cells. J Steroid Biochem Mol Biol. 2004;89–90(1–5):331–4.
PubMed
Google Scholar
Vanderschueren D, Pye SR, O’Neill TW, et al. Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS). J Clin Endocrinol Metab. 2013;98(3):995–1005.
PubMed
CAS
Google Scholar
Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the US. Preventive Services Task Force. Ann Intern Med. 2011;155(12):827–38.
PubMed
Google Scholar
Whayne TF Jr. Vitamin D: popular cardiovascular supplement but benefit must be evaluated. Int J Angiol. 2011;20(2):63–72.
PubMed
PubMed Central
Google Scholar
Shelby J. Needs great, evidence lacking for people with multiple chronic conditions. Scribd. Apr 2013. Accessed 7 May 2013.
Mattke S, Klautzer L, Mengistu T, Hu J, Wu H. Health and well-being in the home: a global analysis of needs, expectations, and priorities for home health care technology. Rand Corporation. 2010. http://www.rand.org/pubs/occasional_papers/OP323.html. Accessed 7 May 2013.
Tseng L. Controversies in vitamin D supplementation. eScholarship. 2003. http://www.escholarship.org/uc/item/4m84d4fn#page-1. Accessed 7 May 2013.
Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2011;(7):CD007470.
Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr. 1995;61(3 Suppl):638S–45S.
PubMed
CAS
Google Scholar
Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69(5):842–56.
PubMed
CAS
Google Scholar
Noordam R, de Craen AJ, Pedram P, et al. Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. CMAJ. 2012;184(18):E963–8.
PubMed
PubMed Central
Google Scholar
Autier P, Boniol M, Pizot C, Mullie P. Vitamin D: chasing a myth? Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2013.
Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2014;4(2):307–20.
PubMed
CAS
Google Scholar
Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53–8.
PubMed
CAS
PubMed Central
Google Scholar
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S–6S.
PubMed
CAS
Google Scholar
Albert PJ, Proal AD, Marshall TG. Vitamin D the alternative hypothesis. Autoimmun Rev. 2009;8(8):639–44.
PubMed
CAS
Google Scholar
Madoff S, editor. The Bacterial L-forms. 1st ed. USA: Marcel Dekker Inc; 1986.
Google Scholar
Allan EJ, Hoischen C, Gumpert J. Bacterial L-forms. Adv Appl Microbiol. 2009;68:1–39.
PubMed
CAS
Google Scholar
Boya P. Lysosomal function and dysfunction: mechanism and disease. Antioxid Redox Signal. 2010;17(5):766–74.
Google Scholar
Domingue GJ, Woody HB. Bacterial persistence and expression of disease. Clin Microbiol Rev. 1997;10(2):320–44.
PubMed
PubMed Central
Google Scholar
O’Connor SM, Taylor CE, Hughes JM. Emerging infectious determinants of chronic diseases. Emerg Infect Dis. 2006;12(7):1051–7.
PubMed
PubMed Central
Google Scholar
Domingue GJ. Demystifying pleomorphic forms in persistence and expression of disease: are they bacteria, and is peptidoglycan the solution? Discov Med. 2010;10(52):234–46.
PubMed
Google Scholar
Rueter A. Microbes start immune response by sneaking inside cells. University of Michigan Health System. Apr 16, 2007. http://www2.med.umich.edu/prmc/media/newsroom/details.cfm?ID=577. Accessed 8 May 2013.
Rolhion N, Darfeuille-Michaud A. Adherent-invasive Escherichia coli in inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(10):1277–83.
PubMed
Google Scholar
Onwuamaegbu ME, Belcher RA, Soare C. Cell wall-deficient bacteria as a cause of infections: a review of the clinical significance. J Int Med Res. 2005;33(1):1–20.
PubMed
CAS
Google Scholar
Verway M, Behr MA, White JH. VitaminD NOD2, autophay and Crohn’s disease. Expert Rev Clin Immunol. 2010;6(4):505–8.
PubMed
Google Scholar
Pirofski L, Casadevall A. Q and A what is a pathogen? A question that begs the point. BMC Biol. 2012;12:6.
Google Scholar
Hof H. Opportunistic intracellular bacteria and immunity. Antibiotic treatment of infections with intracellular bacteria. USA: Springer; 2002.
Fuller E, Elmer C, Nattress F, Horne G, Cook P, Fawcett T. Beta-lactam resistance in Staphylococcus aureus cells that do not require a cell wall for integrity. Antimicrob Agents Chemother. 2005;49(12):5075–80.
PubMed
CAS
PubMed Central
Google Scholar
Wróblewska J, Janicka G, Gospodarek E, Szymankiewicz M. L-forms of Staphylococcus epidermidis induced by penicillin. Pol J Microbiol. 2006;55(3):243–4.
PubMed
Google Scholar
Garssen J, Vandebriel RJ, De Gruijl FR, et al. UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses. Immunology. 1999;97(3):506–14.
PubMed
CAS
PubMed Central
Google Scholar
Riminton DS, Hartung HP, Reddel SW. Managing the risks of immunosuppression. Curr Opin Neurol. 2011;24(3):217–23.
PubMed
Google Scholar
Wall S, Kunze ZM, Saboor S, et al. Identification of spheroplast-like agents isolated from tissues of patients with Crohn’s disease and control tissues by polymerase chain reaction. J Clin Microbiol. 1993;31(5):1241–5.
PubMed
CAS
PubMed Central
Google Scholar
Negi M, Takemura T, Guzman J, et al. Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium. Mod Pathol. 2012;25(9):1284–97.
PubMed
CAS
PubMed Central
Google Scholar
Astrauskiene D, Bernotiene E. New insights into bacterial persistence in reactive arthritis. Clin Exp Rheumatol. 2007;25(3):470–9.
PubMed
CAS
Google Scholar
McDougal JS. Emerging infectious diseases. Centers for Disease Control and Prevention. Mar 2006. http://wwwnc.cdc.gov/eid/article/12/3/05-1409_article.htm#suggestedcitation. Accessed 8 May 2013.
Kozarov E. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol. 2012;8(1):123–38.
PubMed
CAS
PubMed Central
Google Scholar
Khan N, Gowthaman U, Pahari S, Agrewala JN. Manipulation of costimulatory molecules by intracellular pathogens: veni, vidi, vici! PLoS Pathog. 2012;8(6):e1002676.
PubMed
CAS
PubMed Central
Google Scholar
Hajishengallis G, Lambris JD. Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol. 2011;11(33):187–200.
PubMed
CAS
PubMed Central
Google Scholar
Dörr T, Vulić M, Lewis K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol. 2010;8(2):e1000317.
PubMed
PubMed Central
Google Scholar
Fuks JM, Arrighi RB, Weidner JM, et al. GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii. PLoS Pathog. 2012;8(12):e1003051.
PubMed
CAS
PubMed Central
Google Scholar
Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ. Ecology drives a global network of gene exchange connecting the human microbiome. Nature. 2011;480(7376):241–4.
PubMed
CAS
Google Scholar
Riley DR, Sieber KB, Robinson KM, et al. Bacteria–human somatic cell lateral gene transfer is enriched in cancer samples. PLOS Comput Biol. 2013;9(6):e1003107.
PubMed
CAS
PubMed Central
Google Scholar
Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 2014;343(6167):204–208. Available at http://www.sciencemag.org. Accessed 21 Jan 2014.
Eishi Y. Etiologic aspect of sarcoidosis as an allergic endogenous infection caused by Propionibacterium acnes. Biomed Res Int. 2013;2013:935289.
PubMed
PubMed Central
Google Scholar
Wang KX, Chen L. Helicobacter pylori L-form and patients with chronic gastritis. World J Gastroenterol. 2004;10(9):1306–9.
PubMed
Google Scholar
Chen Y, Liu W, Sun T, et al. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting MicroRNA-155-SOCS1 in macrophages. J Immunol. 2013;190(7):3687–95.
PubMed
CAS
PubMed Central
Google Scholar
Nauciel C. Immune defenses against intracellular bacterial infection. In: Paradise LJ, Friedman H, Bendinelli M, editors. Opportunistic intracellular bacteria and immunity. New York: Kluwer Academic; 2002.
Google Scholar
Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770–3.
PubMed
CAS
Google Scholar
Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res. 2001;7(3):167–202.
PubMed
CAS
Google Scholar
McGeachy MJ, McSorley SJ. Microbial-induced Th17: superhero or supervillain? J Immunol. 2012;189(7):3285–91.
PubMed
CAS
PubMed Central
Google Scholar
Oswald-Richter KA, Beachboard DC, Seeley EH, et al. Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL. J Clin Immunol. 2012;32(5):1129–40.
PubMed
CAS
PubMed Central
Google Scholar
Labro M. Interference of antibacterial agents with phagocyte functions: immunomodulation or “immuno-fairy tales”? Clin Microbiol Rev. 2000;13(4):615–50.
PubMed
CAS
PubMed Central
Google Scholar
Giongo A, Gano KA, Crabb DB, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J. 2011;5(1):82–91.
PubMed
CAS
PubMed Central
Google Scholar
Anderson G, Horvath J. The growing burden of chronic disease in America. Public Health Rep. 2004;119(3):263–70.
PubMed
PubMed Central
Google Scholar
Smith G. Angiotensin and systems thinking: wrapping your mind around the big picture. Ochsner J Spring. 2013;13(1):11–25.
Google Scholar
Woolard MD, Frelinger JA. Outsmarting the host: bacteria modulating the immune response. Immunol Res. 2008;41(3):188–202.
PubMed
CAS
Google Scholar
Dermine JF, Desjardins M. Survival of intracellular pathogens within macrophages. Protoplasma. 1999;210(1–2):11–24.
Google Scholar
Xu Y, Xie J, Li Y, et al. Using a cDNA microarray to study cellular gene expression altered by Mycobacterium tuberculosis. Chin Med J (Engl). 2003;116(7):1070–3.
CAS
Google Scholar
Liu PT, Wheelwright M, Teles R, et al. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012;18(2):267–73.
PubMed
CAS
PubMed Central
Google Scholar
Coughlan CA, Chotirmall SH, Renwick J, et al. The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis. Am J Respir Crit Care Med. 2012;186(10):999–1007.
PubMed
CAS
Google Scholar
Yenamandra SP, Lundin A, Arulampalam V, et al. Expression profile of nuclear receptors upon Epstein—Barr virus induced B cell transformation. Exp Oncol. 2009;31(2):92–6.
PubMed
CAS
Google Scholar
Haug CJ, Aukrust P, Haug E, Mørkrid L, Müller F, Frøland SS. Severe deficiency of 1,25-dihydroxyvitamin D3 in human immunodeficiency virus infection: association with immunological hyperactivity and only minor changes in calcium homeostasis. J Clin Endocrinol Metab. 1998;83(11):3832–8.
PubMed
CAS
Google Scholar
Yoshizawa T, Handa Y, Uematsu Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet. 1997;16(4):391–6.
PubMed
CAS
Google Scholar
Sadeghi K, Wessner B, Laggner U, et al. Vitamin D3 down-regulates monocyte TLR expression and triggers. Eur J Immunol. 2006;36(2):361–70.
PubMed
CAS
Google Scholar
Barna BP, Culver DA, Kanchwala A, et al. Alveolar macrophage cathelicidin deficiency in severe sarcoidosis. J Innate Immun. 2012;4(5–6):569–78.
PubMed
CAS
PubMed Central
Google Scholar
Mawer EB, Hayes ME, Still PE, et al. Evidence for nonrenal synthesis of 1,25-dihydroxyvitamin D in patients with inflammatory arthritis. J Bone Miner Res. 1991;6(7):733–9.
PubMed
CAS
Google Scholar
Wang TT, Dabbas B, Laperriere EG, et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285(4):2227–31.
PubMed
CAS
PubMed Central
Google Scholar
Lemire J. 1,25-Dihydroxyvitamin D3—a hormone with immunomodulatory properties. Z Rheumatol. 2000;59(Suppl 1):24–7.
PubMed
CAS
Google Scholar
Deb DK, Chen Y, Zhang Z, et al. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. 296(5):F1212–8.
Mouy R, Fischer A, Vilmer E, Seger R, Griscelli C. Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr. 1989;114(1):555–60.
PubMed
CAS
Google Scholar
Wu S, Sun J. Vitamin D receptor, and macroautophagy in inflammation and infection. Discov Med. 2011;11(59):325–35.
PubMed
PubMed Central
Google Scholar
Domingue G, Turner B, Schlegel JU. Cell-wall deficient bacterial variants in kidney tissue. Detection by immunofluorescence. Urology. 1974;3(3):288–92.
PubMed
CAS
Google Scholar
Pleister A, Eckels DD. Cryptic infection and autoimmunity. Autoimmun Rev. 2003;2(3):126–32.
PubMed
CAS
Google Scholar
Chan TD, Wood K, Hermes JR, et al. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity. 2012;37(5):893–904.
PubMed
CAS
Google Scholar
Blander JM, Torchinsky MB, Campisi L. Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells. Immunol Res. 2012;54(1–3):50–68.
PubMed
CAS
Google Scholar
Christen U, Hintermann E, Holdener M, von Herrath MG. Viral triggers for autoimmunity: is the ‘glass of molecular mimicry’ half full or half empty? J Autoimmun. 2010;34(1):38–44.
PubMed
CAS
PubMed Central
Google Scholar
Proal AD, Albert PJ, Marshall TG. Autoimmune disease and the human metagenome. In: Nelson KE, editor. Metagenomics of the human body. 1st ed. USA: Springer; 2011.
Google Scholar
Berlin T, Zandman-Goddard G, Blank M, et al. Autoantibodies in nonautoimmune individuals during infections. Ann NY Acad Sci. 2007;1108:584–93.
PubMed
CAS
Google Scholar
Molina V, Shoenfeld Y. Infection, vaccines and other environmental triggers of autoimmunity. Autoimmunity. 2005;38(3):235–45.
PubMed
CAS
Google Scholar
Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr. 2003;23:117–45.
PubMed
CAS
Google Scholar
Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188(5):2127–35.
PubMed
CAS
PubMed Central
Google Scholar
Böhm M, Luger TA, Schneider M, Schwarz T, Kuhn A. New insight into immunosuppression and treatment of autoimmune diseases. Clin Exp Rheumatol. 2006;24(1 Suppl 40):S67–71.
PubMed
Google Scholar
Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007;66(9):1137–42.
PubMed
CAS
PubMed Central
Google Scholar
Kim HM, Chung MJ, Chung JB. Remission and relapse of autoimmune pancreatitis: focusing on corticosteroid treatment. Pancreas. 2010;39(5):555–60.
PubMed
CAS
Google Scholar
Collins FS. Reengineering translational science: the time is right. Sci Transl Med. 2011;3(90):9017.
Google Scholar
Norman A. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88(2):491S–9S.
PubMed
CAS
Google Scholar
Rasmussen SB, Reinert LS, Paludan SR. Innate recognition of intracellular pathogens: detection and activation of the first line of defense. APMIS. 2009;117(5–6):323–37.
PubMed
CAS
Google Scholar
Dusso AS, Kamimura S, Gallieni M, et al. gamma-Interferon-induced resistance to 1,25-(OH)2D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses. J Clin Endocrinol Metab. 1997;82(7):2222–32.
PubMed
CAS
Google Scholar
Edfeldt K, Liu PT, Chun R, et al. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci USA. 2010;107(52):22593–8.
PubMed
CAS
PubMed Central
Google Scholar
Lambert PW, Stern PH, Avioli RC, et al. Evidence for extrarenal production of 1 alpha,25-dihydroxyvitamin D in man. J Clin Invest. 1982;69(3):722–5.
PubMed
CAS
PubMed Central
Google Scholar
Reichrath J. Vitamin D and the skin: an ancient friend, revisited. Exp Dermatol. 2007;16(7):618–25.
PubMed
CAS
Google Scholar
Bikle DD. Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep. 2009;7(2):58–63.
PubMed
Google Scholar
Jones G, Prosser DE, Kaufman M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys. 2012;523(1):9–18.
PubMed
CAS
Google Scholar
Xu Y, Hashizume T, Shuhart MC, et al. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006;69(1):56–65.
PubMed
CAS
Google Scholar
Bell NH, Shaw S, Turner RT. Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J Clin Invest. 1984;74(4):1540–4.
PubMed
CAS
PubMed Central
Google Scholar
Waldron JL, Ashby HL, Cornes MP, et al. Vitamin D: a negative acute phase reactant. J Clin Pathol. 2013 (Epub ahead of print).
Ferder M, Inserra F, Manucha W, Ferder L. The world pandemic of Vitamin D deficit could possibly be explained by cellular inflammatory response activity induced by the renin angiotensin system. Am J Physiol Cell Physiol. 2013 (Epub ahead of print).
Akbaraly TN, Hamer M, Ferrie JE, et al. Chronic inflammation as a determinant of future aging phenotypes. CMAJ. 2013 (Epub ahead of print).
Phillips CM, Perry IJ. Does inflammation determine metabolic health status in obese and nonobese adults? J Clin Endocrinol Metab. 2013;98(10):E1610–9.
PubMed
CAS
Google Scholar
Strathmann FG, Laha TJ, Hoofnagle AN. Quantification of 1α,25 dihydroxy vitamin D by immunoextraction and liquid chromatography–tandem mass spectrometry. Clin Chem. 2011;57(9):1279–85.
PubMed
CAS
PubMed Central
Google Scholar
Hollis B. Detection of vitamin D and its major metabolites. In: Feldman D, Pike JW, Glorieux F, editors. vitamin D. San Diego: Elsevier Academic; 2005.
Google Scholar
Perez T. Bacteria induced vitamin D receptor dysfunction in autoimmune disease; theoretical and practical implication for interpretation of serum vitamin D metabolite levels. Paper presented at: 6th International Congress on Autoimmunity, 2006; Porto, Portugal.
Vitamin D Assay Testing. Medicare Limited Coverage Tests—Covered Diagnosis Codes. Nov 14, 2011. Available at http://www.sonoraquest.com/uploads/docs/Vitamin_D_Assay_Testing.pdf?AspxAutoDetectCookieSupport=1. Accessed 31 Jan 2014.
Durup DJHCJSPHALB. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metab. 2012;97(8):2644–52.
PubMed
CAS
Google Scholar
Liu PT, Schenk M, Walker VP, et al. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009;4(6):e5810.
PubMed
PubMed Central
Google Scholar
Carlberg C, Molnar F. Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands. Curr Top Med Chem. 2006;6(12):1243–53.
PubMed
CAS
Google Scholar
Haussler M, Haussler C, Bartik L, et al. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr Rev. 2008;66(10 Suppl 2):98–112.
Google Scholar
Ishizawa M, Matsunawa M, Adachi R, et al. Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia. J Lipid Res. 2008;49(4):763–72.
PubMed
CAS
Google Scholar
Marshall TG, Lee RE, Marshall FE. Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b. Theor Biol Med Model. 2006;3:1.
PubMed
PubMed Central
Google Scholar
Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor-implications of dysregulated vitamin D for diagnosis and treatment of chronic disease. In: Stolzt VD, editor. Vitamin D: New Research. New York: Nova Science Publishers; 2006.
Arao T, Okada Y, Mori H, Nishida K, Tanaka Y. Antihypertensive and metabolic effects of high-dose olmesartan and telmisartan in type 2 diabetes patients with hypertension. Endocr J. 2013; (Epub ahead of print).
Fliser D, Buchholz K, Haller H. Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation. 2004;110(9):1103–7.
PubMed
CAS
Google Scholar
Platten M, Youssef S, Hur EM, et al. Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci USA. 2009;106(35):14948–53.
PubMed
CAS
PubMed Central
Google Scholar
Izu Y, Mizoguchi F, Kawamata A, et al. Angiotensin II type 2 receptor blockade increases bone mass. J Biol Chem. 2009;284(8):4857–64.
PubMed
CAS
Google Scholar
Shimuru H, Nakagami H, Osako MK, et al. Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB J. 2008;22(7):2465–75.
Google Scholar
Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110(2):229–38.
PubMed
CAS
PubMed Central
Google Scholar
Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J. Inflammation and angiotensin II. Int J Biochem Cell Biol. 2003;35(6):881–900.
PubMed
CAS
Google Scholar
Herxheimer K, Martin H. So-called Herxheimer reaction. Arch Derm Syphilol. 1926;13(1):115–7.
Google Scholar
Sonawane A, Santos JC, Mishra BB, et al. Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages. Cell Microbiol. 2011;13(10):1601–17.
PubMed
CAS
Google Scholar
Nickel D, Busch M, Mayer D, Hagemann B, Knoll V, Stenger S. Hypoxia triggers the expression of human beta defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages. J Immunol. 2012;188(8):4001–7.
PubMed
CAS
Google Scholar
Hurley JC. Antibiotic-induced release of endotoxin. A therapeutic paradox. Drug Saf. Mar 1995;12(3):183–95.
Schwocho LR, Masonson HN. Pharmacokinetics of CS-866, a new angiotensin II receptor blocker, in healthy subjects. J Clin Pharmacol. 2001;41(5):515–27.
PubMed
CAS
Google Scholar
Ferrario C. Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil. Vasc Health Risk Manag. 2009;5(1):301–14.
PubMed
CAS
PubMed Central
Google Scholar
Takizawa S, Dan T, Uesugi T, et al. A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage. J Cereb Blood Flow Metab. 2009;29(10):1665–72.
PubMed
CAS
Google Scholar
Proal AD, Albert PJ, Marshall TG, Blaney GP, Lindseth LA. Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. Immunol Res. 2013;56:398–412.
PubMed
CAS
Google Scholar
Hof H. Antibiotic treatment of infections with intracellular bacteria. In: Paradise LJ, Friedman H, Bendinelli M, editors. Opportunistic intracellular bacteria and immunity. New York: Kluwer Academic; 2002.
Google Scholar
Waterhouse JC, Perez TH, Albert PJ. Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease. Ann NY Acad Sci. 2009;1173:757–65.
PubMed
CAS
Google Scholar
Mangin M. Monitoring recovery from autoimmune disease with an interactive, internet-based clinical trial based on a molecular model of chronic disease. Paper presented at: 6th International Congress on Autoimmunity, 2008; Porto, Portugal.
Kongsbak M, Levring TB, Geisler C, von Essen MR. The vitamin D receptor and T cell function. Front Immunol. 2013;4:148.
PubMed
CAS
PubMed Central
Google Scholar