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Interleukin (IL)-23 Receptor, IL-17A and IL-17F Gene Polymorphisms in Brazilian Patients with Rheumatoid Arthritis

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Rheumatoid arthritis (RA) is a progressive, autoimmune disease for which the previous studies have shown that some functional polymorphisms can influence its etiology. Knowing this, the aim of this study was to investigate the association of +2199 A/C IL-23R (rs10889677), −197 G/A IL-17A (rs2275913), and +7488 A/G IL-17F (rs763780) gene polymorphisms with RA susceptibility and clinical features in a Brazilian population. A total of 127 RA patients and 134 healthy controls were recruited for the analyses of polymorphic variants. Genotyping was performed using RFLP-PCR. Logistic regression was used to analyze the genotype distribution of the polymorphisms. Individuals carrying the homozygous CC genotype for the IL-23R polymorphism seem to be at lower risk for RA development (OR 0.22; p = 0.004), as well as those carrying the variant C allele (OR 0.56; p = 0.002). For the −197 G/A IL-17A polymorphism, the wild-type genotype (GG) was significantly associated with a 3.18-fold (OR 3.18; p = 0.033) increased risk for RA. In relation to the +7488 A/G IL-17F polymorphism, no significant difference was found between RA cases and control subjects (p > 0.05). Moreover, when investigating the relationship between polymorphisms and clinical features, no evidence of an association was found. Our findings suggest that the variants +2199 A/C IL-23R and −197 G/A IL-17A could contribute to RA development in the studied population. However, larger studies are needed to fully understand this genetic predisposition.

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Acknowledgements

This work was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Authors and Affiliations

  1. Pós-Graduate Program in Applied Cellular and Molecular Biology, University of Pernambuco, Recife, PE, Brazil

    Isaura Isabelle Fonseca Gomes da Silva

  2. Federal Institute of Pernambuco, Garanhuns, PE, Brazil

    Hildson Dornelas Angelo

  3. Division of Clinical Rheumatology, University of Pernambuco, Recife, PE, Brazil

    Eliezer Rushansky & Maria Helena Mariano

  4. Department of Biology, Federal Rural University of Pernambuco, Recife, PE, Brazil

    Maria de Mascena Diniz Maia

  5. Departamento de Biologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, CEP 52171-900, Brazil

    Paulo Roberto Eleuterio de Souza

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  1. Isaura Isabelle Fonseca Gomes da Silva
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  2. Hildson Dornelas Angelo
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  3. Eliezer Rushansky
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  4. Maria Helena Mariano
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  5. Maria de Mascena Diniz Maia
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  6. Paulo Roberto Eleuterio de Souza
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Correspondence to Paulo Roberto Eleuterio de Souza.

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Gomes da Silva, I.I.F., Angelo, H.D., Rushansky, E. et al. Interleukin (IL)-23 Receptor, IL-17A and IL-17F Gene Polymorphisms in Brazilian Patients with Rheumatoid Arthritis. Arch. Immunol. Ther. Exp. 65, 537–543 (2017). https://doi.org/10.1007/s00005-017-0473-7

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  • DOI: https://doi.org/10.1007/s00005-017-0473-7

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