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Antioxidative constituents fromlycopus lucidus

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Abstract

Three phenolic compounds, rosmarinic acid (1), methyl rosmarinate (2), ethyl rosmarinate (3), and two flavonoids, luteolin (4), luteolin-7-O-β-D-glucuronide methyl ester (5) were isolated from the aerial part ofLycopus lucidus (Labiatae). Their structures were determined by chemical and spectral analysis. Compounds1-5 exhibited potent antioxidative activity on the NBT superoxide scavenging assay. The IC50 values for compounds 1–5 were 2.59, 1.42, 0.78, 2.83, and 3.05 μg/mL respectively. In addition, five compounds were isolated from this plant for the first time.

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References

  • Akdemir, Z. Ş., Tati, II., Saraccoglu, I., ismailoğlu, U. B., SahinErdemli, I., and Caliş, I., Polyphenolic compounds fromGeranium pratense and their free radical scavenging activities.Phytochemistry, 56, 189–193 (2001).

    Article  PubMed  CAS  Google Scholar 

  • Dapkevicius, A., Beek, T. A., Lelyveld, G. P., Veldhuizen, A., Groot, A., Linssen, J. P. H., and Venskutonis, R., Isolation and structure elucidation of radical scavengers fromThymus vulgaris leaves.J. Nat. Prod., 65, 892–896 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Do, J. C., Chai, J. Y., and Son, J. K., Studies on the constituents ofLycopus lucidus (I).Kor. J. Pharmacogn., 22, 162–165 (1991a).

    CAS  Google Scholar 

  • Do, J. C., Chai, J. Y., and Son, J. K., Studies on the constituents ofLycopus lucidus (II).Kor. J. Pharmacogn., 22, 166–170 (1991b).

    CAS  Google Scholar 

  • Hou, Z.-F., Tu, Y.-Q., and Li, Y., Three new phenolic compounds fromNepeta prattii.J. Chin. Chem. Soc., 49, 255–258 (2002).

    CAS  Google Scholar 

  • Kirby, A. J. and Schmidt, R. J., The antioxidant activity of Chinese herbs for eczema and of placebo herbs - I.J. Ethnopharmacol., 56, 103–108 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Kuo, Y.-H., Lee, S.-M., and Lai, J.-S., Constituents of the whole herb ofClinoponium laxiflorum.J. Chin. Chem. Soc., 47, 241–246 (2000).

    CAS  Google Scholar 

  • Lee, M. H., Son, Y. K., and Han, Y. N., Tissue factor inhibitory flavonoids from the fruits ofChaenomeles sinensis.Arch. Pharm. Res., 25, 842–850 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Matsuda, H., Cai, H., Kubo, M., Tosa, H., and Inuma, M., Study on anti-cataract drugs from natural sources. II. Effects on Buddlejae Flos onin vitro aldose reductase activity.Biol. Pharm. Bull., 18, 462–466 (1995).

    Google Scholar 

  • Okamura, N., Haraguchi, H., Hashimoto, K., and Yagi, A., Flavonoids inRosmarinus officinalis leaves.Phytochemistry, 37, 1463–1466 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Pietta, P-G., Flavonoids as antioxidants.J. Nat. Prod., 63, 1035–1042 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Schulz, M., Strack, D., Weissenbock, G., Markham, K. R., Dellamonica, G., and Chopin, J., Two luteolin O-glucuronides from primary leaves ofSecale cereale.Phytochemistry, 24, 343–345 (1985).

    Article  CAS  Google Scholar 

  • Wang, Y., Ohtani, K., Kasai, R., and Yamasaki, K., Flavonol glycosides and phenolics from leaves ofCordia dichotoma.Nat. Med., 50, 367–367 (1996).

    CAS  Google Scholar 

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Correspondence to Eun-Rhan Woo.

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Woo, ER., Piao, M.S. Antioxidative constituents fromlycopus lucidus . Arch Pharm Res 27, 173–176 (2004). https://doi.org/10.1007/BF02980102

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  • DOI: https://doi.org/10.1007/BF02980102

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