Abstract
Restriction endonuclease fragment length variations (RFLV) were detected by use of the cDNA probeHox-3.1 for the homeo box-3.1 gene and also thec-myc oncogene probe for exon 2. RFLV ofHox-3.1 were found inHindIII restriction patterns, and RFLV of theMyc-1.2 gene inEcoRV patterns. From the RFLV, theHox-3.1 andMyc-1.2 genes were mapped on chromosome 15. Three-point cross test data showed that the frequency of recombination is 26.4% betweenMyc-1.2 andGpt-1, 30.2% betweenGpt-1 andGdc-1, and 9.4% betweenGdc-1 andHox-3.1. The following order of these genes is proposed,Myc-1.2—Gpt-1—Gdc-1—Hox-3.1. All laboratory strains carry theHox-3.1 a andMyc-1.2 a alleles. Among strains of wild origin,domesticus strains carry only theHox-3.1 a andMyc-1.2 a alleles, as do the laboratory strains. One strain ofbrevirostris carries theHox-3.1 a andMyc-1.2 b alleles. Other wild subspecies from Europe and Asia,M. m. musculus, M. m. castaneus, M. m. molossinus, Chinese mice of wild origin, andM. m. yamashinai carry theHox-3.1 b andMyc-1.2 b alleles.
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Watanabe, T., Ohno, K., Shimizu, A. et al. Mapping of theHox-3.1 andMyc-1.2 genes on chromosome 15 of the mouse by restriction fragment length variations. Biochem Genet 28, 257–266 (1990). https://doi.org/10.1007/PL00020677
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DOI: https://doi.org/10.1007/PL00020677