Abstract
8-Methylquinoline-5-carboxylic acid was obtained by the Skraup reaction from 3-amino-p-toluic acid or by hydrolysis of 5-cyano-8-methylquinoline. The latter was synthesized by the Rosenmund-von Braun reaction from 5-bromo-8-methylquinoline, which was obtained by bromination of 8-methylquinoline in the presence of silver sulfate. Bromination in the side chain of 8-methylquinoline-5-carboxylic acid and its nitrile was studied.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 366–368, March, 1980.
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Gracheva, I.N., Tochilkin, A.I. Synthesis and bromination of 8-methylquinoline-5-carboxylic acid. Chem Heterocycl Compd 16, 275–277 (1980). https://doi.org/10.1007/PL00020570
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DOI: https://doi.org/10.1007/PL00020570