Abstract
Concentration of benzylpenicillin filtered broths purified by ultrafiltration and fermented broths clarified by ultrafiltration was carried out by reverse osmosis. This study was done using a reverse osmosis laboratory/pilot installation from Paterson Candy International Ltd. whose module has a tubular configuration and a membrane with a molecular weight cut-off of 100 Dalton (ZF99) made of a polyamide film with a rejection of 99% of NaCl.
It was concluded that reverse osmosis is an adequate technique to concentrate benzylpenicillin ultrafiltered broths, leading to low losses of benzylpenicillin in the permeate and high benzylpenicillin recovery for high volumetric concentration factors.
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Received: 28 January 1999
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Nabais, A., Cardoso, J. Concentration of ultrafiltered benzylpenicillin broths by reverse osmosis. Bioprocess Engineering 22, 41–44 (2000). https://doi.org/10.1007/PL00009098
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DOI: https://doi.org/10.1007/PL00009098