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The effect of cataract on sleep time and quality in late adulthood

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Abstract

Aims: This study was undertaken to evaluate the effect of senile cataract on sleep profiles. Methods: Clinical interviews and comprehensive ophthalmological examinations were done on 378 patients over 59 years old. Severities of cataract as a whole (LO: lenticular opacity) and nucleosclerosis (LN: lenticular nucleosclerosis) were determined by the LOCS (Lens Opacities Classification System) III. PSQI (Pittsburgh Sleep Quality Index) was performed to determine sleep profiles. HAS (Hospital Anxiety-Depression Scale) was performed to evaluate emotional status. The relationship between total sleep time per night (TST), wake-up time and bed time with LO and LN were evaluated. Results: LO and LN were both associated with earlier bed- and wake-up times, but only bed time and LN had significant association (p=0.0006). PSQI sleep quality subscale and global scores were significantly higher with advanced LN (p=0.017, p=0.018). Conclusion: Advanced nucleosclerosis is associated with earlier bed time and lower quality of sleep. Stimulus by appropriate light to the eye is necessary for the physiologic regulation of sleep.

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References

  1. Lubkin V, Beizai P, Sadun AA. The eye as metronome of the body. Survey Ophthalmol 2002; 47: 17–26.

    Article  Google Scholar 

  2. Middleton B, Arendt J, Stone BM. Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time. J Sleep Res 1996; 5: 69–76.

    Article  CAS  PubMed  Google Scholar 

  3. Hiddinga AE, Beersma DG, Van den Hoofdakker RH. Endogenous and exogenous components in the circadian variation of core body temperature in humans. J Sleep Res 1997; 6: 156–63.

    Article  CAS  PubMed  Google Scholar 

  4. Czeisler CA, Duffy JF, Shanahan TL et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 1999; 284: 2177–81.

    Article  CAS  PubMed  Google Scholar 

  5. Lockley SW, Skene DJ, Arendt J, Tabandeh H, Bird AC, Defrance R. Relationship between melatonin rhythms and visual loss in the blind. J Clin Endocrinol Metab 1997; 82: 3763–70.

    CAS  PubMed  Google Scholar 

  6. Sack RL, Lewy AJ, Blood ML, Keith LD, Nakagawa H. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. J Clin Endocrinol Metab 1992; 75: 127–34.

    CAS  PubMed  Google Scholar 

  7. Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. Nonphotic entrainment of the human circadian pacemaker. Am J Physiol 1998; 274: R991–6.

    CAS  PubMed  Google Scholar 

  8. Hellman L, Nakada F, Curti J et al. Cortisol is secreted episodically by normal man. J Clin Endocrinol Metab 1970; 30: 411–22.

    Article  CAS  PubMed  Google Scholar 

  9. Khalsa SB, Jewett ME, Cajochen C, Czeisler CA. A phase response curve to single bright light pulses in human subjects. J Physiol 2003; 549: 945–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol 2000; 526: 695–702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Brainard GC, Hanifin JP, Greeson JM et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci 2001; 21: 6405–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Rimmer DW, Boivin DB, Shanahan TL, Kronauer RE, Duffy JF, Czeisler CA. Dynamic resetting of the human circadian pacemaker by intermittent bright light. Am J Physiol Regul Integr Comp Physiol 2000; 279: 9.

    Article  Google Scholar 

  13. Neubauer DN. Sleep problems in the elderly. Am Fam Physician 1999; 59: 2551–9.

    CAS  PubMed  Google Scholar 

  14. Czeisler CA, Allan JS, Strogatz SH et al. Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science 1986; 233: 667–71.

    Article  CAS  PubMed  Google Scholar 

  15. Kolker DE, Fukuyama H, Huang DS, Takahashi JS, Horton TH, Turek FW. Aging alters circadian and light-induced expression of clock genes in golden hamsters. J Biol Rhythms 2003; 18: 159–69.

    Article  CAS  PubMed  Google Scholar 

  16. Campbell SS, Kripke DF, Gillin JC, Hrubovcak JC. Exposure to light in healthy elderly subjects and Alzheimer’s patients. Physiol Behav 1988; 42: 141–4.

    Article  CAS  PubMed  Google Scholar 

  17. Charman WN. Age, lens transmittance, and the possible effects of light on melatonin suppression. Ophthalm Physiol Optics 2003; 23: 181–7.

    Article  CAS  Google Scholar 

  18. Asplund R, Ejdervik Lindblad B. The development of sleep in persons undergoing cataract surgery. Arch Gerontol Geriatr 2002; 35: 179–87.

    Article  CAS  PubMed  Google Scholar 

  19. Asplund R, Lindblad BE. Sleep and sleepiness 1 and 9 months after cataract surgery. Arch Gerontol Geriatr 2004; 38: 69–75.

    Article  CAS  PubMed  Google Scholar 

  20. Congdon N, Vingerling JR, Klein BE et al. Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 2004; 122: 487–94.

    Article  PubMed  Google Scholar 

  21. Klein BE, Klein R, Lee KE. Incidence of age-related cataract over a 10-year interval: the Beaver Dam Eye Study. Ophthalmology 2002; 109: 2052–7.

    Article  PubMed  Google Scholar 

  22. Klein BE, Klein R, Linton KL. Prevalence of age-related lens opacities in a population. The Beaver Dam Eye Study. Ophthalmology 1992; 99: 546–52.

    Article  CAS  PubMed  Google Scholar 

  23. Lopes de Faria JM, Russ H, Costa VP. Retinal nerve fibre layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol 2002; 86: 725–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Meyer-Rüsenberg B, Pavlidis M, Stupp T, Thanos S. Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy. Graefe’s archive for clinical and experimental ophthalmology 2006; 245: 1009–18.

    Article  PubMed  Google Scholar 

  25. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213.

    Article  CAS  PubMed  Google Scholar 

  26. Karbassi M, Khu PM, Singer DM, Chylack LT. Evaluation of lens opacities classification system III applied at the slitlamp. Optom Vis Sci 1993; 70: 923–8.

    Article  CAS  PubMed  Google Scholar 

  27. Davison JA, Chylack LT. Clinical application of the lens opacities classification system III in the performance of phacoemulsification. J Cataract Refract Surg 2003; 29: 138–45.

    Article  PubMed  Google Scholar 

  28. van den Berg TJ, Coppens JC. Conversion of lens slit lamp photographs into physical light-scattering units. Invest Ophthalmol Vis Sci 1999; 40: 2151–7.

    PubMed  Google Scholar 

  29. Weale RA. Human lenticular fluorescence and transmissivity, and their effects on vision. Exp Eye Res 1985; 41: 457–73.

    Article  CAS  PubMed  Google Scholar 

  30. Rajput V, Bromley SM. Chronic insomnia: a practical review. Am Fam Physician 1999; 60: 1431–8 (discussion 41).

    CAS  PubMed  Google Scholar 

  31. Oh SM, Min KJ, Park DB. A Study on the standardization of the Hospital Anxiety and Depression Scale for Koreans. J Korean Neuropsychiatr Assoc 1999; 28: 289–96.

    Google Scholar 

  32. Freedman MS, Lucas RJ, Soni B et al. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 1999; 284: 502–4.

    Article  CAS  PubMed  Google Scholar 

  33. Hattar S, Liao HW, Takao M, Berson DM, Yau KW. Melanopsincontaining retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 2002; 295: 1065–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol 2001; 535: 261–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Mainster MA, Sparrow JR. How much blue light should an IOL transmit? Br J Ophthalmol 2003; 87: 1523–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Tanito M, Kaidzu S, Anderson RE. Protective effects of soft acrylic yellow filter against blue light-induced retinal damage in rats. Exp Eye Res 2006; 83: 1493–504.

    Article  CAS  PubMed  Google Scholar 

  37. Bok D. Evidence for an inflammatory process in age-related macular degeneration gains new support. Proc Natl Acad Sci USA 2005; 102: 7053–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Edwards AO, Ritter R 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science 2005; 308: 421–4.

    Article  CAS  PubMed  Google Scholar 

  39. Hageman GS, Anderson DH, Johnson LV et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 2005; 102: 7227–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Klein RJ, Zeiss C, Chew EY et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308: 385–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Magnusson KP, Duan S, Sigurdsson H et al. CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med 2006; 3: e5.

    Article  PubMed  Google Scholar 

  42. Cruickshanks KJ, Klein R, Klein BE. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol 1993; 111: 514–8.

    Article  CAS  PubMed  Google Scholar 

  43. Tomany SC, Cruickshanks KJ, Klein R, Klein BE, Knudtson MD. Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol 2004; 122: 750–7.

    Article  PubMed  Google Scholar 

  44. Taylor HR, West S, Munoz B, Rosenthal FS, Bressler SB, Bressler NM. The long-term effects of visible light on the eye. Arch Ophthalmol 1992; 110: 99–104.

    Article  CAS  PubMed  Google Scholar 

  45. Roberts JE. Ocular phototoxicity. J Photochem Photobiol B 2001; 64: 136–43.

    Article  CAS  PubMed  Google Scholar 

  46. Augustin AJ, Dick HB, Offermann I, Schmidt-Erfurth U. [The significance of oxidative mechanisms in diseases of the retina]. Klin Monbl Augenheilkd 2002; 219: 631–43.

    Article  PubMed  Google Scholar 

  47. Klein R, Klein BE, Wang Q, Moss SE. Is age-related maculopathy associated with cataracts? Arch Ophthalmol 1994; 112: 191–6.

    Article  CAS  PubMed  Google Scholar 

  48. van der Schaft TL, Mooy CM, de Bruijn WC, Mulder PG, Pameyer JH, de Jong PT. Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens. Br J Ophthalmol 1994; 78: 441–5.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Wang JJ, Mitchell PG, Cumming RG, Lim R. Cataract and agerelated maculopathy: the Blue Mountains Eye Study. Ophthalmic Epidemiol 1999; 6: 317–26.

    Article  CAS  PubMed  Google Scholar 

  50. Klein R, Klein BE, Jensen SC, Cruickshanks KJ. The relationship of ocular factors to the incidence and progression of age-related maculopathy. Arch Ophthalmol 1998; 116: 506–13.

    Article  CAS  PubMed  Google Scholar 

  51. Klein R, Klein BE, Wong TY, Tomany SC, Cruickshanks KJ. The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. Arch Ophthalmol 2002; 120: 1551–8.

    Article  PubMed  Google Scholar 

  52. Chang JR, Koo E, Agron E et al. Risk factors associated with incident cataracts and cataract surgery in the Age-related Eye Disease Study (AREDS): AREDS report number 32. Ophthalmology 2011; 118: 2113–9.

    Article  PubMed  Google Scholar 

  53. Delcourt C, Carriere I, Delage M, Barberger-Gateau P, Schalch W. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Invest Ophthalmol Vis Sci 2006; 47: 2329–35.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, The Catholic University of Korea, Yeouido St. Mary’s Hospital, 62 Yeouido-dong, Youngdeungpo-gu, Seoul, 150-713, South Korea

    Yeong Hoon Kim

  2. Department of Neuropsychiatry, The Catholic University of Korea, Yeouido St. Mary’s Hospital, 62 Yeouido-dong, Youngdeungpo-gu, Seoul, 150-713, South Korea

    Kyu In Jung

  3. Department of Family Medicine, College of Medicine, The Catholic University of Korea, Yeouido St. Mary’s Hospital, 62 Yeouido-dong, Youngdeungpo-gu, Seoul, 150-713, South Korea

    Chan Hee Song MD, PhD

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  1. Yeong Hoon Kim
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Correspondence to Chan Hee Song MD, PhD.

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Kim, Y.H., Jung, K.I. & Song, C.H. The effect of cataract on sleep time and quality in late adulthood. Aging Clin Exp Res 24, 663–668 (2012). https://doi.org/10.1007/BF03654831

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