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The cold-induced TSH secretion is resistant to alterations in the physicochemical properties of the intracerebral infusions

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Abstract

The purpose of the present study was to see how different methodological factors affect TSH secretion in male rats. The cold-induced TSH secretion was rather resistant to variations in the volume, pH and osmolality of solutions infused bilaterally into the anterior hypothalamus or into the 3rd ventricle of the rat brain. Only rather high pH (11.30) and osmolality (870 mosmol/kg) significantly inhibited theTSH cold-response. A short term immobilization (sham-infusion) or ether anaesthesia did not cause any significant alterations in TSH secretion. It is concluded that the cold-induced TSH secretion is not easily affected by nonspecific methodological factors.

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References

  1. Weiner R.J., Ganong W,F. Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol. Rev. 58: 905, 1978.

    PubMed  CAS  Google Scholar 

  2. Müller E.E., Nistico G., Scapagnini U. Neurotransmitters and anterior pituitary function. Academic Press, New York, 1977, p. 1.

    Google Scholar 

  3. Annunziato L., DiRenzo G.F., Lombardi G., Scopacasa F., Schettini G., Preziosi P., Scapagnini U. The role of central noradrenergic neurons in the control of thyrotropin secretion in the rat. Endocrinology 100: 738, 1977.

    Article  PubMed  CAS  Google Scholar 

  4. Scapagnini U., Annunziato L., DiRenzo G.F., Schettini G., Preziosi P. Effects of clonidine on basal and cold-stimulated TSH secretion. Arch. Int. Pharmacodyn. Ther. 230: 220,1977.

    PubMed  CAS  Google Scholar 

  5. Männistö P., Ranta T., Tuomisto J. Dual action of adrenergic system on the regulation of thyrotropin secretion in the male rat. Acta Endocrinol. (Kbh.) 90: 249, 1979.

    Google Scholar 

  6. Schettini G., Quattrone A., DiRenzo G., Lombardi G., Preziosi P. Effect of 6-hydroxydopamine treatment on TSH secretion in basal and cold-stimulated conditions in the rat. Eur. J. Pharmacol. 56: 153, 1979.

    Article  PubMed  CAS  Google Scholar 

  7. Ranta T., Männistö P., Tuomisto J. Evidence for dopaminergic control of thyrotropin secretion in the rat. J. Endocrinol. 72: 329, 1977.

    Article  PubMed  CAS  Google Scholar 

  8. Annunziato L., DiRenzo G.F., Schettini G., Lombardi G., Scopacasa F., Scapagnini U., Preziosi P. Lack of evidence for an inhibitory role played by tubero-infundibular dopaminergic neurons on TSH secretion in the rat. Neuroendocrinology 28: 435, 1979.

    Article  PubMed  CAS  Google Scholar 

  9. Männistö Mattila J., Kaakkola S. Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat. Eur. J. Pharmacol. 76: 403, 1981.

    Article  PubMed  Google Scholar 

  10. DiRenzo G.F., Quattrone A., Schettini G., Preziosi P. Effect of quipazine and d-fenfluramine, two serotoninlike drugs, on TSH secretion in basal and cold-stimulated conditions in the rat. Life Sci. 22: 1879, 1978.

    Article  CAS  Google Scholar 

  11. Krulich L., Vijayan E., Coppings R.J., Giachetti A., McCann S.M., Mayfield M.A. On the role of central serotoninergic system in the regu lation of the secretion of thyrotropin and prolactin: Thyrotropin-inhibiting and prolactin-releasing effects of 5-hydroxytryptamine and quipazine in the male rat. Endocrinology 105: 276, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Mattila J., Männistö P.T. Modification of GABAergic activity and thyrotropin secretion in male rats. Acta Pharmacol. Toxicol. (Kbh.) 47: 241, 1980.

    Article  CAS  Google Scholar 

  13. Hefco E., Krulich L., Miner P., Larsen P.R. Effect of acute exposure to cold on the activity of the hypothalamic-pituitary-thyroid system. Endocrinology 97: 1185, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. König J.F.R., Klippel R.A. The rat brain. A stereotaxic atlas of the forebrain and lower parts of the brain stem. The Williams and Wilkins company, Baltimore, 1963, p. 1.

    Google Scholar 

  15. Myers R.D. Handbook of drug and chemical stimulation of the brain. Medical Economics Book Division, New Jersey, 1974, p. 1.

    Google Scholar 

  16. Iversen L.L., Iversen S.D., Snyder S.H. Handbook of psychopharmacology. Plenum Press, New York, 1975, Vol. 1, p. 1.

    Google Scholar 

  17. Reichlin S., Martin J.B., Mitnick M.A., Boshans R.L., Grimm Y., Bollinger J., Gordon J., Malacara J. The hypothalamus in pituitary-thyroid regulation. Recent Prog. Horm. Res. 28: 229, 1972.

    PubMed  CAS  Google Scholar 

  18. Männistö P.T., Saarinen A., Ranta T. Anesthetics and thyrotropin secretion in the rat. Endocrinology 99: 875, 1976.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Helsinki, Siltavuorenpenger 10A, SF-00170, Helsinki 17, Finland

    J. Mattila, R. Tuominen & P. Männistö

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  1. J. Mattila
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  2. R. Tuominen
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  3. P. Männistö
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Mattila, J., Tuominen, R. & Männistö, P. The cold-induced TSH secretion is resistant to alterations in the physicochemical properties of the intracerebral infusions. J Endocrinol Invest 6, 225–228 (1983). https://doi.org/10.1007/BF03350612

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  • DOI: https://doi.org/10.1007/BF03350612

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