Skip to main content
SpringerLink
Log in

Hormonal profile in benign breast disease. Endocrine status of cyclical mastalgia patients

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Plasma levels of prolactin, before and after TRH stimulation, progesterone, estradiol, sex-hormone-binding-globulin, androstenedione, testosterone and dehydroepiandrosterone-sulphate were determined in a group of women with benign breast disease and in control group, in order to correlate a possible hormonal disorder to breast pathology. The hormonal pattern in the patients with benign breast disease was characterized by an increased responsiveness of lactotrophes to TRH stimulation and by higher levels of sex hormone binding globulin, probably sustained by an underlying hyperestrogenism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Welsch C.W., Dombroske S.E., MacManus M.J., Calaf J. Effect of human, bovine and ovine prolactin on DNA synthesis by organ cultures of benign breast tumors. Br. J. Cancer 40: 866, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  2. Gorins A., Netter A. La prolactin, son dosage radioimmunologique dans le cancer sein et les mastopathies benigne de la femme. Nouv. Presse Med. 3: 73, 1974.

    PubMed  CAS  Google Scholar 

  3. Malarkey W.B, Schroeder L.L., Stevens V.C., James A.G., Lanese R.R. Disordered nocturnal prolactin regulation in women with breast cancer. Cancer Res. 37: 4650, 1977.

    PubMed  CAS  Google Scholar 

  4. Rose D.P., Lahti H., Laakso K., Kettunen K., Wynder E.L. Serum and breast duct fluid prolactin and estrogen levels in healthy finnish and american women and patients with fibrocystic disease. Cancer 57: 1550, 1986.

    Article  PubMed  CAS  Google Scholar 

  5. Geller S., Scholler R., Amalric R., Ayme Y., Spitalier J.M. Le test combiné’ LHRH + TRH dans les mastopathies dites “hormonales”. Nouv. Presse Med. 7: 1563, 1978.

    PubMed  CAS  Google Scholar 

  6. Peters F., Pickardt C.R., Zimmermann G., Breckwoldt M. PRL, TSH and thyroid hormones in benign breast disease. Klin. Wochenschr. 59: 403, 1981.

    Article  PubMed  CAS  Google Scholar 

  7. Peters F., Schuth W., Scheurich B., Breckwoldt M. Serum prolactin levels in patients with fibrocystic disease. Obstet. Gynecol. 49: 381, 1984.

    Google Scholar 

  8. Dogliotti L., Faggiuolo R., Ferusso A., Orlandi F., Sandrucci S., Tibo A, Angeli A. Prolactin and thyrotropin response to TRH in premenopausal women with fibrocystic disease of the breast. Horm. Res. 21: 137, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Kumac S., Mansel R.E., Hughes L.E., Edwards C.A., Scanion M.F. Prediction of response to endocrine therapy in pronounced cyclical mastalgia using dynamic tests of prolactin release. Clin. Endocrinol. (Oxf.) 23: 699, 1985.

    Article  Google Scholar 

  10. Mauvais-Jarvis P., Kutten F., Mowszcowicz J., Sitruk-Ware R. Mastopathies benignes: étude hormonale chez 125 malades. Nouv. Presse Med. 6: 4115, 1977.

    PubMed  CAS  Google Scholar 

  11. Walsh P.V., Bulbrook R.D., Stell P.M., Wang D.J., McDicken J.W., George W.D. Serum progesterone concentration during the luteal phase in women with benign breast disease. Eur. J. Cancer Clin. Oncol. 20: 411, 1984.

    Article  Google Scholar 

  12. Bruning P.F., Bonfrer J.M.G., Bobrow L., De Jong-Bakker M., Hart A.A.M., Misdorp W. Plasma hormones in premenopausal women with benign breast disease. In: Angeli A., Bradlow H.L., Dogliotti L. (Eds.), Endocrinology of the breast: basic and clinical aspects. Raven Press, New York, 1986, p. 579.

    Google Scholar 

  13. Miller W.R., Humeniuk V., Kelley R.W. Dehydroepiandrosterone sulphate in breast secretions. J. Steroid Biochem. 13: 143, 1980.

    Article  Google Scholar 

  14. Bradlow H.L., Rosenfeld R.S, Kream J., Fleisher M., O’Connor J., Schwartz M.K. Steroid hormone accumulation in human breast cyst fluid. J. Clin. Endocrinol. Metab. 49: 778, 1981.

    Article  Google Scholar 

  15. Miller W.R., Dixon J.M., Scott W.N., Forrest A.P.M. Classification of human breast cysts according to electrolyte and androgen conjugate composition. Clin. Oncol. 9: 227, 1983.

    PubMed  CAS  Google Scholar 

  16. Dogliotti L., Orlandi F., Torta M., Buzzi G., Naldoni C., Mazzotti A., Angeli A. Cations and dehydroepiandrosterone-sulphate in cyst fluid of pre- and menopausal patients with gross cystic disease of the breast. Evidence for the subpopulations of cysts. Eur.J. Clin. Oncol. 22: 1301, 1986.

    Article  CAS  Google Scholar 

  17. Cole E.N., Sellwood R.A., England P.C., Griffiths K. Serum prolactin concentrations in benign breast disease throughout the menstrual cycle. Eur. J. Cancer 15: 1185, 1981.

    Google Scholar 

  18. Walsh P.V., McDicken I.W., Bulbrook R.D., Moore J.W., Taylor W.H., George W.D. Serum oestradiol-17β and prolactin concentrations during the luteal phase in women with benign breast disease. Eur. J. Cancer Clin. Oncol. 20: 1345, 1984.

    Article  PubMed  CAS  Google Scholar 

  19. Tarquini B., Gheri R., Romano S.R., Costa A., Cagnoni M., Lee J.K., Halberg F. Circadian variations of serum prolactin and TSH of women with health or with mammary carcinoma, fibroadenomata or fibrocystic mastopathy. Int. J. Chronobiol. 7: 101, 1980.

    PubMed  CAS  Google Scholar 

  20. Vorherr H. Thyroid disease in realtion to breast cancer. Klin. Wochenschr. 56: 1139, 1978.

    Article  PubMed  CAS  Google Scholar 

  21. Massara F., Camanni F., Vergano V., Belforte L., Molinatti G.M. Inhibition of thyrotropin and prolactin secretion by dopamine in man. J. Endocrinol. Invest. 1: 25, 1978.

    Article  PubMed  CAS  Google Scholar 

  22. Scanlon M.F., Weightman D.R., Shale D.J., Mora B., Heath M., Snow G., Hall R. Dopamine is a physiological regulator of thyrotropin (TSH) secretion in normal man. Clin. Endocrinol. (Oxf.) 10: 7, 1979.

    Article  CAS  Google Scholar 

  23. Rodriguez-Arnao M.D., Peters J.R., Foord S.M., Dieguez C., Edwards C., Gomez-Pan A., Hall R., Newcombe R.G., Scanlon M.F. Exaggerated circadian variation in basal thyrotropin (TSH) and in the dopaminergic inhibition of TSH release in pathological hyperprolactinemia: evidence against a hypothalamic dopaminergic defect. J. Clin. Endocrinol. Metab. 57: 975, 1983.

    Article  PubMed  CAS  Google Scholar 

  24. Leong D.A., Frawley L.S., Neill J.D. Neuroendocrine control of prolactin secretion. Ann. Rev. Physiol. 45: 109, 1983.

    Article  CAS  Google Scholar 

  25. Melis G.B., Guameri G., Paoletti A.M., Petacchi F.D., Ricci G., Strigini F., Selli M., Ruiu A., Fioretti P. Clinical significance of hormonal evaluation in peripheral blood and in breast cyst fluid of women with benign breast disease. In: Angeli A., Bradlow H.L., Dogliotti L. (Eds.), Endocrinology of cystic breast disease. Raven Press, New York, 1983, p. 101.

    Google Scholar 

  26. Marchesoni D., Gangemi M., Mozzanega B., Nardelli G.B., Miggino T., Verlasco M. Hormonal investigation in benign breast disease. In: Angeli A., Bradlow H.L., Dogliotti L. (Eds.), Endocrinology of cystic breast disease. Raven Press, New York, 1983, p. 145.

    Google Scholar 

  27. England P.C., Skinner L.G., Cottrell K.M., Sellwood R.A. Sex hormones in breast disease. Br. J. Surg. 62: 806, 1975.

    Article  PubMed  CAS  Google Scholar 

  28. Swain M.C., Hayward J.L., Bulbrook R.D. Plasma estradiol and progesterone in benign breast disease. Eur. J. Cancer 9: 553, 1973.

    Article  PubMed  CAS  Google Scholar 

  29. Berta L., Frairia R., Bumma C., Navello C., Mossetti C., Rovero E., Gaidano G. Hormonal pattern and sex hormone binding globulin in plasma of women with cystic breast disease. In: Angeli A., Bradlow H.L., Dogliotti L. (Eds.), Endocrinology of cystic breast disease. Raven Press, New York, 1983, p. 123.

    Google Scholar 

  30. Carlstrom K., Doberl A., Gershagen S., Rannevik., Rasmussen T, Tobiassen T. Elevated peripheral levels of androgens and a some sensitive steroid plasma proteins in patients with severe fibrocystic breast disease. Acta Obstet. Gynecol. Scand. (Suppl.) 123: 157, 1984.

    Article  CAS  Google Scholar 

  31. Kratochwil K., Durnberger H., Heuberger B., Wasner G. Hormone-induced cell and tissue interaction in the embryonic mammary gland. Cold Spring Harbor Conferences on Cell Proliferation 6: 717, 1979.

    Google Scholar 

  32. Miller W.R., Dixon J.M., Forrest P.M. Hormonal correlates of apocrine secretion in the breast. In: Angeli A., Bradlow H.L., Dogliotti L. (Eds.), Endocrinology of the breast: basic and clinical aspects, Raven press, New York, 1986, p. 275

    Google Scholar 

  33. Poortman J., Prenen J.A.C., Thijssen J.H.H., Schwarz F. Interaction of 5-androstene-3β-17β-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue. J. Clin. Endocrinol. Metab. 40: 373, 1975.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del S. Cuore, Largo A. Gemelli, 8, 00168, Roma, Italy

    E. Parlati, A. Travaglini & S. Dell’Acqua

  2. Istituto di Chimica Biologica, Servizio di Analisi Ormonali. Facoltà di Medicina, Università Cattolica del S. Cuore, 00168, Roma, Italy

    I. Liberale & E. Menini

Authors
  1. E. Parlati
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Travaglini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. Liberale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Menini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Dell’Acqua
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parlati, E., Travaglini, A., Liberale, I. et al. Hormonal profile in benign breast disease. Endocrine status of cyclical mastalgia patients. J Endocrinol Invest 11, 679–683 (1988). https://doi.org/10.1007/BF03350214

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350214

Key-words

Search

Navigation