Abstract
A normal pituitary-gonadal function is reinduced by iv or sc pulsatile LHRH therapy, administered by a portable pump. In order to evaluate the differences between different sites of injection on the LHRH bioavailability, we compared the LHRH plasma concentration after a single LHRH injection in the lower abdominal wall and in the upper arm, in 5 patients with idiopathic hypogonadotropic hypogonadism, during LHRH treatment. Our data showed no significant differences in using both administration routes. In fact, LHRH absorption (secretory area and peak value) is quite similar. However, patients tolerated LHRH administration in the abdominal wall more so than in the upper arm. Both ways of administration are effective with regards to the pituitary responsiveness but we can not forget that patients compliance is of great importance in order to obtain the best results in a long-term therapy.
Similar content being viewed by others
References
Belchetz P.E., Plant T.M., Nakamara Y., Keogh E., Knobil E. Hypophisial responses to continuos and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 202: 631, 1978.
Crowley W.F., Filicori M., Spratt D.J., Santoro N.F. The physiology of gonatropin-releasing hormone (GnRH) secretion in men and women. Recent Progr. Horm. Res. 41: 473, 1985.
Clayton R.N. Gonadotropin-releasing hormone: from physiology to pharmacology. Clin. Endocrinol. (Oxf.) 26: 361, 1987.
Seibel M.M., Claman P., Oskowitz S.P., Mc Ardle C., Weinstein F.G. Events surrounding the initiation of puberty with long-term subcutaneous pulsatile gonadotropin-releasing hormone in female patients with Kallmann’s Syndrome. J. Clin. Endocrinol. Metab. 61: 575, 1985.
Stanhope R.. Brook G.D., Adams J., Jakobs M.S. Induction of puberty by pulsatile gonadotropin-releasing hormone. Lancet 2: 552, 1987.
Handelsman D.J., Swerdloff R.S. Pharmacokinetics of gonadotropin-releasing hormone and its analogs. Endocr. Rev. 7: 95, 1986.
Valk T.W., Corley K.P., Kelch R.P., Marshall J.C. Hypogonadotropic hypoganodism: hormonal response to low dose pulsatile administration of gonadotropin-releasing hormone. J. Clin. Endocrinol. Metab. 51: 730, 1980.
Skarin G., Nillius S., Wide L. Pulsatile subcutaneous low-dose gonadotropin-releasing hormone treatment of anovulatory infertility. Fertil. Steril. 40: 450 1983.
Giusti M., Torre R., Traverso L., Cavagnaro P., Attanasio R., Giordano G. Clinical use of low-dose pulsatile LHRH treatment in males with hypogonadotropic hypogonadism (HH). J. Steroid Biochem. 28: 135A, 1987.
Hoffman A.R., Crowley W.F. Induction of puberty in man by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N. Engl. J. Med. 307: 1237, 1982.
Blunt S.M., Clayton R.N., Butt R.W. Effect of injection site on the pharmacokinetics and pharmacodynamics of subcutaneously administered luteinizing hormone releasing hormone. Clin. Endocrinol. (Oxf.) 25: 289, 1976.
Spratt D.J., Carr D.B., Merriam G.R., Scully R.E., Narashima Rao P., Crowley W.F. The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopatic hypogondotropic hypogonadism: clinical and laboratory correlations. J. Clin. Endocrinol. Metab. 64: 283, 1987.
Delitala G., Giusti M., Mazzocchi G., Granziera L., Tarditi W., Giordano G. Participation of endogenous opiates in regulation of the hypotalamic-pituitary-testicular axis in normal man. J. Clin. Endocrinol. Metab. 57: 1277, 1983.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Torre, R., Traverso, L., Cavagnaro, P. et al. Injection sites and pharmacokinetic of luteinizing hormone releasing hormone: comparison of two different subcutaneous administration routes. J Endocrinol Invest 12, 601–603 (1989). https://doi.org/10.1007/BF03350012
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03350012