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Short-term effects of somatostatin analogue (SMS 201–995) on left ventricular function in healthy persons: A scintigraphic study

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Abstract

Since somatostatin has been reported to have a negative inotropic and chronotropic effect on atria and positive inotropic effect on ventricle, present study was designed to investigate the acute effects of somatostatin analogue SMS 201–995 infusion on the left ventricular function in healthy volunteers. After labeling the autologous red blood cells with 750–1000 MBq 99mTc-perthecnetate, ECG-gated radionuclide ventriculography was performed. Using Fourier analysis of the left ventricular time-activity curve, ejection fraction (EF), peak ejection rate (PER), peak filling rate (PFR), time to endsystole (TES) and normalized TES/T values were calculated. Study group consisted of 12 healthy volunteers. Somatostatin analogue SMS 201–995 infusion was given at a rate of 100 μg/h during 2h. Baseline, 1st, 2nd h and 4th h imagings were done using the same protocol. Simultaneously heart rate and blood pressure were recorded. The difference between parameters was tested using Kruskall-Wallis test. The mean heart rate, systolic and diastolic blood pressures and did not show any statistically significant change during the somatostatin analogue infusion and 2h later in comparison to baseline values. The mean PER and PFR had a slight decrease at the first hour of infusion, but the change was not significant. However, the significant correlation of PER values with heart rate, EF and TES observed at baseline study were disappeared during the infusion. These results indicate that somatostatin analogue infusion does not appear to change the left ventricular systolic and diastolic function in healthy persons significantly.

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References

  1. Krulich L., Dhariwal A.P.S., McCann S.M. Stimulary and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83: 783, 1968.

    Article  CAS  PubMed  Google Scholar 

  2. Brazeau P., Vale W., Burgus R., Ling N., Butcher M., Rivier J., Guillemin R. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pitutary growth hormone. Science 179: 77, 1973.

    Article  CAS  PubMed  Google Scholar 

  3. Hokfelt T., Johansson O., Ijungdahl A., Lundberg J.M., Schultzberg M. Peptidergic neurones. Nature 109: 55, 1980.

    Google Scholar 

  4. Polak J.M., Pearse A.G.E., Grimelius L., Bloom S.R., Arimura A. Growth hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet 1: 1220, 1975.

    Article  CAS  PubMed  Google Scholar 

  5. Quirion R., Regoli D., Rioux F., St-Pierre S. An analysis of the negative inotrophic action of somatostatin. Br. J. Pharmacol. 66: 251, 1979.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Rioux F., Kerouac R., St-Pierre S. Somatostatin: Interaction with the sympathetic nervous system in Guinea pigs. Neuropeptides 1: 319, 1981.

    Article  CAS  Google Scholar 

  7. Diez J., Tamargo J., Valenzuela C. Negative inotropic effect of somatostatin in Guineapig atrial fibres. Br. J. Pharmacol. 86: 547, 1985.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Lin C.I., Su M.T., Luk H.N., Wu H.L Suppressive effects of somatostatin in the dog Purkinje fibers. Br. J. Pharmacol. 93: 192, 1988.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Corvetti G., Androetti L., Sisto-Daneo L. Chick heart peptidergic innervation: Localization and development. Basic Appl. Histochem. 32: 485, 1988.

    CAS  PubMed  Google Scholar 

  10. Day S.M., Gu J., Polak J.M., Bloom S.R. Somatostatin in the human heart and comparison with Guinea-pig and rat heart. Br. Heart J. 53: 153, 1985.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Greco A.V., Ghirlando G., Barone C., Bertoli A., Caputo S., Uccioli L, Manna R. Somatostatin in paroxysmal supraventricular and junctional tachycardia. Br. Med. J. 288: 28, 1984.

    Article  CAS  Google Scholar 

  12. Ghirlando G., Santarelli P., Uccioli L., Sandric S., Bellocci F., Bianchini G., Cotronese P., Greco A.V. Electrophysiologic effects of somatostatin in man. Peptides 7: 265, 1986.

    Article  Google Scholar 

  13. Webb S.C., Krikler D.M., Hendry W.G., Adrian T.E., Bloom S.R. Electrophysiological actions of somatostatin on the atrioventricular junction in sinus rhythm and reentry tachycardia. Br. Heart J. 56: 236, 1986.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Franco-Cereceda A., Bergston L., Lundberg J.M. Inotropic effects of calcitonin gene-related peptide, vasointestinal peptide and somatostatin on the human right atrium in vitro. Eur J. Pharmacol. 134: 69, 1987.

    Article  CAS  PubMed  Google Scholar 

  15. Hou Z.Y., Lin C.I., Chiu T.H., Chiang B.N., Cheng K.K., Ho L.T. Somatostatin effects in isolated human atrial fibres. J. Mol. Cell. Cardiol. 19: 177, 1987.

    Article  CAS  PubMed  Google Scholar 

  16. Bauer W., Briner U., Doepner W., Haller R., Huguenin R. SMS 201–995, a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci. 31: 1133, 1982.

    Article  CAS  PubMed  Google Scholar 

  17. Lambert S.V.J., Uitterlinden P., Verschoor L., Van Dongen K.J., Del Pozo E. Long-term treatment of acromegaly with the somatostatin analogue SMS 201–995. N. Eng. J. Med. 373: 1576, 1985.

    Article  Google Scholar 

  18. Thuesen L., Christensen S.E., Weeke J., Orskov H., Henningsen P. The cardiovascular effects of octreotide treatment in acromegaly: An echocardiographic study. Clin. Endocrinol. (Oxf.) 30: 619, 1989.

    Article  CAS  Google Scholar 

  19. Chanson P., Timsit J., Masquet C., Warnet A., Guillausseau P.J., Birman P., Harris A.G., Lubetzki J. Cardiovascular effects of the somatostatin analogue octreotide in acromegaly. Ann. Intern. Med. 113: 921, 1990.

    Article  CAS  PubMed  Google Scholar 

  20. Brown M.R., Gray T.S. Peptide injections into the amygdala of concious rats. Effects on blood pressure, heart rate and plasma catecholamines. Regul. Pept. 21: 95, 1988.

    Article  CAS  PubMed  Google Scholar 

  21. Brown M.R. Somatostatin-28 effects on central nervous system regulation of vasopressin secretion and blood pressure. Neuroendocrinology. 47: 556, 1988.

    Article  CAS  PubMed  Google Scholar 

  22. Wiley J.W., Uccioli L., Owyong C., Yamado T. Somatostatin stimulates acetylcholine release in the canine heart. Am. J. Physiol. 257: H483, 1989.

    CAS  PubMed  Google Scholar 

  23. Schroder T., Millard R.W., Nakajima Y., Gabel M., Joffe S.N. Microcirculatory effects of somatostatin in acute pancreatitis. Eur. Surg. Res. 20: 82, 1988.

    Article  CAS  PubMed  Google Scholar 

  24. Savi L., Cardillo C., Bombardieri G. Somatostatin and peripheral blood flow in man. Angiology 36: 511, 1985.

    Article  CAS  PubMed  Google Scholar 

  25. Endou M., Hattari Y., Nakaya H., Kanno M. Differential effects of somatostatin on atrial and ventricular contractile responses in Guinea pig heart: Influence of pretreatment with islet-activating protein. J. Pharmacol. Exp. Ther. 250: 726, 1989.

    CAS  PubMed  Google Scholar 

  26. Hiari S., Hasegawa J., Mashiba H. Positive inotropic effect of somatostatin in Guineapig ventricular muscles. J. Mol. Cell. Cardiol. 21: 607, 1989.

    Article  Google Scholar 

  27. Lim M.J., Barkan A.L., Buda A.J. Rapid reduction of left ventricular hypertrophy in acromegaly after supression of growth hormone. Ann. Intern. Med. 117: 719, 1992.

    Article  CAS  PubMed  Google Scholar 

  28. Jansen R.W., Lenders J.W., Peeters T.L., von Lier H.J., Hoefnagels W.H. SMS 201–995 prevents postprandial blood pressure reduction in normotensive and hypertensive elderly subjects. J. Hypertension 6: 669, 1989.

    Article  Google Scholar 

  29. Kooner J.S., Peart W.S., Mathias C.J. The peptide release inhibitor, Ocreotide (SMS 201–995) prevents the haemodynamic changes following food ingestion in normal human subjects. Q. J. Exp. Physiol. 74: 569, 1989.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, Dept. of Endocrinology, Hacettepe University, Turkey

    B. Erbas, E. Varoglu, T. Aras & C. Bekdik

  2. Dept. of Nuclear Medicine, Hacettepe University, Ankara, Turkey

    T. Erbas M.D. & A. Usman

Authors
  1. T. Erbas M.D.
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  2. A. Usman
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  3. B. Erbas
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  4. E. Varoglu
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  5. T. Aras
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  6. C. Bekdik
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Erbas, T., Usman, A., Erbas, B. et al. Short-term effects of somatostatin analogue (SMS 201–995) on left ventricular function in healthy persons: A scintigraphic study. J Endocrinol Invest 16, 857–861 (1993). https://doi.org/10.1007/BF03348943

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