Abstract
A 56-year-old woman with granulomas of gold thioglucose in her hips exhibited recurrent bouts of hypoglycemic attacks. The first attack occurred 2 years after the last injection of gold thioglucose, when large amounts of extractable insulin and human insulin-specific antibody were noted in her serum. Histological examination of the resected granulomas showed marked infiltration of lymphocytes, plasma cells, and macrophages containing yellowish-brown granules, which proved to be gold by electron microscopy using X-ray microanalysis. After resection of the granuloma, however, the frequency of the hypoglycemic attacks decreased remarkably as well as the levels of both extractable insulin and human insulin-specific antibody.
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Yao, K., Uchigata, Y., Kyono, H. et al. Human insulin-specific immunoglobulin G antibody and hypoglycemic attacks after the injection of gold thioglucose. J Endocrinol Invest 15, 43–47 (1992). https://doi.org/10.1007/BF03348654
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DOI: https://doi.org/10.1007/BF03348654