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Isolated corticotrophin deficiency presenting with pericardial effusion

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Abstract

Isolated ACTH deficiency is a rare disorder often presenting with long-standing aspecific symptoms combined with unusual clinical presentations. We here describe a patient in whom pericardial effusion was part of the clinical presentation and fully resolved on steroid at replacement dosage, highlighting the possibility of hypoadrenalism as an additional cause of pericardial effusion of unknown origin.

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References

  1. de Luis DA, Aller R, Romero E. Isolated ACTH deficiency. Horm Res 1998, 49: 247–9.

    Article  PubMed  Google Scholar 

  2. Soler-Soler J, Sagristà-Sauleda J, Permanyer-Miralda G. Management of pericardial effusion. Heart 2001, 86: 235–40.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Gharib H, Hodgsen SF, Gatineau CF, et al. Reversible hypothyroidism in Addison’s disease. Lancet 1972, 2: 734–6.

    Article  CAS  PubMed  Google Scholar 

  4. Fallo F, Betterle C, Budano S, Lupia M, Boscaro M, Sonino N. Regression of cardiac abnormalities after replacement therapy in Addison’s disease. Eur J Endocrinol 1999, 140: 425–8.

    Article  CAS  PubMed  Google Scholar 

  5. Jialal I, Desai RK, Maharaj IC, Pala AS, Joubert SM. Isolated adrenocorticotrophic hormone (ACTH) deficiency associated with acute adrenal crisis. Postgrad Med J 1985, 61: 423–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Iga K, Hori K, Gen H. Deep negative T waves associated with reversible left ventricular dysfunction in acute adrenal crisis. Heart Vessels 1992, 7: 107–11.

    Article  CAS  PubMed  Google Scholar 

  7. Torfoss D, von der Lippe E, Jacobsen D. Cardiac tamponade preceding adrenal insufficiency-an unusual presentation of Addison’s disease: a report of two cases. J Intern Med 1997, 241: 25–8.

    Google Scholar 

  8. Arlt W, Allolio B. Adrenal insufficiency. Lancet 2003, 361: 1881–93.

    Article  CAS  PubMed  Google Scholar 

  9. Otsuka F, Yamamoto K, Shimada N, Kageyama J, Ogura T, Makino H. Cholestatic jaundice: an unusual symptom of isolated adrenocorticotropin deficiency in adults. J Endocrinol Invest 2004, 27: 404–5.

    CAS  PubMed  Google Scholar 

  10. Atkin SL, Masson EA, White MC. Isolated adrenocorticotropin deficiency presenting as primary infertility. J Endocrinol Invest 1995, 18: 456–9.

    Article  CAS  PubMed  Google Scholar 

  11. Pulichino AM, Vallette-Kasic S, Couture C, et al Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. Genes Dev 2003, 17: 711–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Correspondence to F. Cavagnini.

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Pecori Giraldi, F., Fatti, L.M. & Cavagnini, F. Isolated corticotrophin deficiency presenting with pericardial effusion. J Endocrinol Invest 28, 831–833 (2005). https://doi.org/10.1007/BF03347576

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  • DOI: https://doi.org/10.1007/BF03347576

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