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Effects of lighting conditions and of hormone replacement on the level of porphyrins in the rat Harderian gland

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Abstract

The effects of lighting conditions and/or gonadal secretions on the porphyrins of rat Harderian glands were studied. In female rats, exposure to constant light (=LL) induced a 50% decrease of porphyrin in the Harderian gland. Ovariectomy in these animals caused an increase to levels comparable to those found in intact controls. In males, exposure to constant darkness (= DO) produced a marked increase in the glandular porphyrins together with greatly decreased weights of accessory sexual organs. Further, orchidectomy remarkably increased porphyrin levels in rats kept under conditions of LL or DD. Administration of testosterone propionate to castrated male rats significantly decreased the porphyrin contents in the gland, although estradiol benzoate and progesterone treatments had no effect on the levels. Similar results were obtained in female rats.

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References

  1. Walls G.L. The vertebrate eye and its adaptive radiation. Bloomfield Hills: Cranbrook Institute of Science, Bulletin 19, 1942.

    Book  Google Scholar 

  2. Sakai T. The mammalian Harderian gland: Morphology, biochemistry, function and physiology. Arch. Histol. Jpn. 44: 299, 1981.

    Article  PubMed  CAS  Google Scholar 

  3. Wetterberg L., Geller E., Yuwiler A. Harderian gland: an extraretinal photoreceptor influencing the pineal gland in the neonatal rats. Science 167: 884, 1970.

    Article  PubMed  CAS  Google Scholar 

  4. Reiter R.J., Klein D.O. Observations on the pineal gland, Harderian gland, the retina and the reproductive organs of adult female rats exposed to continuous light. J. Endocrinol. 51: 117, 1971.

    Article  PubMed  CAS  Google Scholar 

  5. Clabough J.W., Norvell J.E. Effects of castration, blinding, and the pineal gland on the Harderian glands of the male golden hamster. Neuroendocrinology 12: 344, 1973.

    Article  PubMed  CAS  Google Scholar 

  6. Shirama K. Induction of persistent estrus by constant light: Effect of neonatal constant light and Harderian gland function. Neuroendocrinology 27: 193, 1978.

    Article  PubMed  CAS  Google Scholar 

  7. Wetterberg L., Nystrom B., Nilsson O. Effect of lighting conditions on the porphyrin content and morphology of the Harderian gland and on uterine morphology in the golden hamster. Experientia 28: 1084, 1972.

    Article  PubMed  CAS  Google Scholar 

  8. Shirama K., Takeo Y., Shimizu K., Maekawa K. Influences of continuous lighting intensities on porphyrin content in rat Harderian gland. Zool. Mag. 86: 259, 1977.

    CAS  Google Scholar 

  9. Hoffman R.J. Influence of some endocrine glands, hormones and blinding on the histology and porphyrins of the Harderian glands of golden hamster. Am. J. Anat. 132: 463, 1971.

    Article  PubMed  CAS  Google Scholar 

  10. Payne A.P., McGadey J., Moore M.R., Thompson G.G. Cyclic and seasonal changes in Harderian gland activity in the female golden hamster. J. Endocrinol. 72: 41P, 1977.

    Article  Google Scholar 

  11. Payne A.P., McGadey J., Moore M.R., Thompson G.G. Androgenic control of the Harderian gland in the male golden hamster. J. Endocrinol. 75: 73, 1977.

    Article  PubMed  CAS  Google Scholar 

  12. Payne A.P., McGadey J., Moore M.R., Thompson G.G. Changes in Harderian gland activity in the female golden hamster during the estrous cycle, pregnancy and lactation. Biochem. J. 178: 597, 1979.

    PubMed Central  PubMed  CAS  Google Scholar 

  13. Shirama K., Furuya T., Takeo Y., Shimizu K., Maekawa K. Influences of some endocrine glands and of hormone replacement on the porphyrins of the Harderian glands of mice. J. Endocrinol. 91: 305, 1981.

    Article  PubMed  CAS  Google Scholar 

  14. Reiter R.J., Fraschini F. Endocrine aspects of the mammalian pineal gland: a review. Neuroendocrinology 5: 219, 1969.

    Article  PubMed  CAS  Google Scholar 

  15. Rosenfield R.J., Tones T., Dupon C., Fang V.S., Anderson W.A. Androgens and ovarian structure in constant estrus. J. Endocrinol. 65: 283, 1975.

    Article  PubMed  CAS  Google Scholar 

  16. Dupon C., Kim M.H. Peripheral plasma levels of testosterone, androstenedione, and oestradiol during rat oestrous cycle. J. Endocrinol. 59: 653, 1973.

    Article  PubMed  CAS  Google Scholar 

  17. Thompson G.G., Hordovatzi X., Moore M.R., McGadey J., Payne A.P. Sex differences in haem biosynthesis and porphyrin content in the Harderian gland of the golden hamster. Int. J, Biochem. 16: 849, 1984.

    Article  CAS  Google Scholar 

  18. Wooley G.W., Workley J. Sexual dimorphism in the Harderian gland of the hamster (Cricetus auratus). Anat. Rec. 118: 416, 1954.

    Google Scholar 

  19. Formgren B., Wetterberg L. Uroporphyrinogen-III-cosynthetase activity in the Harderian gland of the golden hamster. Enzyme 16: 146, 1973.

    PubMed  CAS  Google Scholar 

  20. Ulrich R., Yuwiler A., Geller E., Wetterberg L. Effects of sex hormones and environmental lighting on rat Harderian gland porphyrin. J. Endocrinol. 63: 99, 1974.

    Article  PubMed  CAS  Google Scholar 

  21. Pang S.F., Brown G.M., Grota L.J., Rodman R.L. Radioimmunoassay of melatonin in the pineal glands, Harderian glands, retinas and sera of rats or chickens. Fed. Proc. 6: 691 (abstr.), 1976.

    Google Scholar 

  22. Bubenik G.A., Brown G.M., Grota L.J. Immunohistological localization of melatonin in the rat Harderian gland. J. Histochem. Cytochem. 24: 1173, 1976.

    Article  PubMed  CAS  Google Scholar 

  23. Joo I., Kahan A. The porphyrin content of the Harderian glands in rats and the melatonin-melanocyte stimulating hormone system. Endokrinologie 65: 308, 1975.

    PubMed  CAS  Google Scholar 

  24. Hoffman R.A., Johnson L.B., Reiter R.J. Harderian glands of golden hamsters: temporal and sexual differences in immunoreactive melatonin. J. Pineal Res. 2: 161, 1985.

    Article  PubMed  CAS  Google Scholar 

  25. Payne A.P., McGadey J., Johnson H.S. Interstitial porphyrins and tubule degeneration in the hamster Harderian gland. J. Anat. 140: 25, 1985.

    PubMed Central  PubMed  Google Scholar 

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  1. Department of Anatomy, Tokyo Medical College, Shinjuku-ku, Tokyo, 160, Japan

    Kazuhiko Shirama, M. Kohda & M. Hokano

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  1. Kazuhiko Shirama
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  2. M. Kohda
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  3. M. Hokano
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Shirama, K., Kohda, M. & Hokano, M. Effects of lighting conditions and of hormone replacement on the level of porphyrins in the rat Harderian gland. J Endocrinol Invest 10, 79–82 (1987). https://doi.org/10.1007/BF03347160

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  • DOI: https://doi.org/10.1007/BF03347160

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