Abstract
The goal of the work is a comparative study of the effect of constant illumination depending on the time of onset of exposure (from one month to 14 months of age) on the development of a number of oncological and age-related diseases in male rats. The results of the study show that a decrease in the functional activity of the pineal gland under the influence of constant illumination from one month of age increases the incidence of inflammatory, nontumor, and tumor genesis and leads to the rapid development of age-related pathology. Conversely, rat maintenance in constant light mode from 14 months of age slows the development of age-related pathology and reduces the incidence and development of malignant tumors.
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Statement on the welfare of animals. Animal maintenance complied with the principles of good laboratory practice and order of the Ministry of Healthcare and Social Development of the Russian Federation as of August 23, 2010 no. 708n “On Approval of the Rules of Laboratory Practice” [9, 14]. The work was performed in compliance with the international principles of the Helsinki Declaration on the Humane Attitude towards Animals, the principles of humanity set forth in the European Community Directive (2010/63/EU), “Bioethical Rules for Conducting Research on Humans and Animals,” “Rules of Conducting Work Using Experimental Animals,” “Sanitary and Epidemiological Requirements for the Organization, Equipment, and Maintenance of Experimental Biological Clinics (Vivaria)”, in accordance with the “Guideline for Laboratory Animals and Alternative Models in Biomedical Technology,” as well as the regulations under Good Laboratory Practices (GLP) [9, 16, 20].
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Matveeva, Y.P., Zhukova, O.V., Lotosh, T.A. et al. The Role of Constant Light Exposure in Various Periods of Postnatal Ontogenesis in the Development of Pathology and Mortality in Male Rats. Adv Gerontol 9, 141–146 (2019). https://doi.org/10.1134/S2079057019020164
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DOI: https://doi.org/10.1134/S2079057019020164