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The 769G>A variant of the inhibin-α gene in Korean patients with preeclampsia

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Abstract

Objective: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHα) gene was associated with preeclampsia. Patients and methods: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHα gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing. Results: We found no variation between the normal subjects and the preeclamptic patients. Conclusion: The 769G>A variant of the INHα gene may be rare in Korean patients with preeclampsia.

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Authors and Affiliations

  1. The Laboratory of Medical Genetics, Korea

    S. Y. Kim, J. H. Lim & S. Y. Park

  2. Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Kwandong University School of Medicine, 1-19 Mukjeong-dong, Jung-gu, Seoul, 100-380, Korea

    J. H. Yang, M. Y. Kim, M. H. Kim & H. M. Ryu MD, PhD

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  1. S. Y. Kim
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  2. J. H. Lim
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  3. J. H. Yang
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  4. M. Y. Kim
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  5. M. H. Kim
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  6. S. Y. Park
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  7. H. M. Ryu MD, PhD
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Correspondence to H. M. Ryu MD, PhD.

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Kim, S.Y., Lim, J.H., Yang, J.H. et al. The 769G>A variant of the inhibin-α gene in Korean patients with preeclampsia. J Endocrinol Invest 31, 700–703 (2008). https://doi.org/10.1007/BF03346418

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