Abstract
Aging is characterized by a decrease in bone volume, implying that net bone resorption exceeds net bone formation. This age- related bone loss can be regarded as the main determinant of hip fracture risk in the elderly. In the concept of senile osteoporosis, a key role has been attributed to vitamin D deficiency. Lack of vitamin D activity may affect femoral strength through impaired mineralization as well as through a hyperparathy- roidism- mediated increase in bone resorption. In addition to vitamin D- related mechanisms, recent evidence has indicated a decline in the skeletal content of anabolic growth factors — such as insulin- like growth factor- I (IGF- I) — in femoral (cortical) bone, suggesting that skeletal growth factor deficiency may contribute to the age- related bone loss in the proximal femur as well. It is tempting to speculate that skeletal IGF- I loss might, at least partially, be accounted for by growth hormone deficiency. However, critical evidence does not yet support the concept that the decreased activity of the growth hormone- IGF- I- axis alters bone remodeling, and the extent to which serum concentrations of growth factors are reflective of skeletal activity remains to be clarified.
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Boonen, S., Aerssens, J., Broos, P. et al. Age-related bone loss and senile osteoporosis: Evidence for both secondary hyperparathyroidism and skeletal growth factor deficiency in the elderly. Aging Clin Exp Res 7, 414–422 (1995). https://doi.org/10.1007/BF03324355
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DOI: https://doi.org/10.1007/BF03324355