Skip to main content
SpringerLink
Log in

Searching for the molecular basis of aging: The need for life extension models

  • Editorial
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Goldstein S.: Human genetic disorders that feature premature onset and accelerated progression of biological aging. In: Schneider E.L. (Ed.), The Genetics of Aging. Plenum Press, New York, 1978, pp. 171–224.

    Chapter  Google Scholar 

  2. Medawar P.B.: An unsolved problem of biology. H.K. Lewis, London, 1952.

    Google Scholar 

  3. Williams G.C.: Pleiotropy, natural selection and the evolution of senescence. Evolution 11: 398–411, 1957.

    Article  Google Scholar 

  4. Charlesworth B.: Evolution in age-structured populations. Cambridge University Press, Cambridge, 1980.

    Google Scholar 

  5. Rose M.R., Charlesworth B.: A test of evolutionary theories of senescence. Nature 287: 141–142,1980.

    Article  PubMed  CAS  Google Scholar 

  6. Luckinbill L.S., Clare M.J.: Selection for life span in Drosophila melanogaster. Heredity 55: 9–18,1985.

    Article  PubMed  Google Scholar 

  7. Lints F.A.: Genetics. In: Lints F.A., Soliman M.H., (Eds.), Drosophila as a model organism for ageing studies. Blackie, Glasgow, 1988, pp. 99–118.

    Google Scholar 

  8. Franceschi C: Cell proliferation, cell death and aging. Aging. 1: 3–15,1989.

    PubMed  CAS  Google Scholar 

  9. Tedesco P.M., Link CD., Hutchinson E.W., Johnson T.E.: Cloning a gene for life-extension in Caenorhabditis elegans. In: Finch C.E., Johnson T.E. (Eds.), Molecular Biology of Aging. Wiley-Liss, New York, 1990, pp. 3–17.

    Google Scholar 

  10. Shepherd J.C.W., Walldorf U., Hug P., Gehring W.J.: Fruit flies with additional expression of the elongation factor EF-lα live longer. Proc. Natl. Acad. Sci. USA 86: 7520–7521,1989.

    Article  PubMed  CAS  Google Scholar 

  11. David J.R.: Temperature. In: Lints F.A., Soliman M.H. (Eds.), Drosophila as a model organism for ageing studies. Blackie, Glasgow, 1988, pp. 33–45.

    Google Scholar 

  12. Pearl R.: The rate of living. Alfred Knopf, New York, 1929.

    Google Scholar 

  13. Weindruch R., Walford R.L.: The retardation of aging and disease by dietary restriction. Thomas, Springfield, 1988.

    Google Scholar 

  14. Austad S.N.: Life extension by dietary restriction in the bowl and doily spider, Frontinella pyramitela. Exp. Gerontol. 24: 83–92,1989.

    Article  PubMed  CAS  Google Scholar 

  15. Masoro E.J., Shimokawa I., Yu B.P.: Retardation of the aging processes in rats by food restriction. In: Pierpaoli W., Fabris N. (Eds.), Physiological senescence and its postponement. Theoretical approaches and rational interventions. Annals of the New York Academy of Sciences (in press).

  16. Gordon J.: The human genome project promises insights into aging. Geriatrics 44: 89–91, 1989.

    PubMed  CAS  Google Scholar 

  17. Vijg J., Gossen J.A., Slagboom P.E., Uitterlinden A.G.: New methods for the detection of DNA sequence variation: applications in molecular studies on aging. In: Finch C.E., Johnson T.E. (Eds.), Molecular Biology of Aging. Wiley-Liss, New York, 1990, pp. 103–119.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biology, TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands

    Jan Vijg (Ph.D.)

Authors
  1. Jan Vijg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vijg, J. Searching for the molecular basis of aging: The need for life extension models. Aging Clin Exp Res 2, 227–229 (1990). https://doi.org/10.1007/BF03323922

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03323922

Keywords

Search

Navigation